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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $461.1 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Int J Mol Med.2015, 35(5):1237-45Ind Crops Prod.2015, 67:185-191Evid Based Complement Alternat Me...2017...Universite de Bordeaux...2017...Sci Rep.2017, 7(1):3249Nat Prod Sci.2018, 24(2):109-114Korean Journal of Pharmacognosy...2018...Biochem Biophys Res Commun....2018...
Sci Rep.2018, 8:9267J Chromatogr B Analyt Technol Bio...2019...Chemistry of Plant Materials....2019...Chemistry of Vegetable Raw Materi...2019...Phytomedicine.2019, 58:152893Planta Med.2019, 85(3):217-224Front Plant Sci.2020, 10:1705Evid-Based Compl Alt2020, 7202519:13
Nutrients.2020, 12(12):3638.JABS2020, 14:2(2020)Int J Mol Sci.2020, 21(9):3392. J Med Food.2020, 23(6):633-640.Biomol Ther (Seoul)....2020...Pharmacol Rep.2020, 72(2):472-480.J of Pharmaceutical Analysis...2020...
Our products had been exported to the following research institutions and universities, And still growing.
University of Lodz (Poland)Chang Gung University (Taiwan)University of Maryland (USA)University of Hawaii Cancer Center (USA)
Universitas islam negeri Jakarta (Indonesia)Technical University of Denmark (Denmark)Kamphaengphet Rajabhat University (Thailand)Universiti Putra Malaysia(UPM) (Malaysia)
Chiang Mai University (Thailand)University of the Basque Country (Spain)Celltrion Chemical Research Ins... (Korea)
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Ulm University Medical Center2020, doi: 10.18725.Plant Foods Hum Nutr.2020, 10.1007Journal of functional foods2018, 171-182J Nat Med.2021, doi: 10.1007.Exp Biol Med (Maywood).2019, 244(18):1665-1679J Basic Clin Physiol Pharmacol.2016, 27(1):1-8Nutrients.2018, 10(7)Korean J of Pharmacognosy2020, 51,49-54.Int J Mol Med.2020, 45(5):1514-1524.Plant Cell Tiss Org2017, 479-486
Related Screening Libraries
Gynosaponin TN-2 exerts protective effects on L-DOPA (100 and 200 μM)-induced apoptotic cell death by modulating extracellular signal-regulated protein kinases 1 and 2 activation in pheochromocytoma 12 cells.
|Neuroreport, 2018 Jan 3;29(1):1-5 |
|Effects of gynosaponin TN-2 on L-DOPA-induced cytotoxicity in PC12 cells[Pubmed: 29120941]|
|Gynosaponins have pharmacological effects on 3,4-L-dihydroxyphenylalanine (L-DOPA)-related or dopamine-related neurological diseases; however, the neuroprotective functions of single compound of gynosaponins remain undefined. This study investigated the cytotoxic effects of gynosaponin TN-2 on L-DOPA in pheochromocytoma 12 cells. Gynosaponin TN-2, at 0.5-3 μM, did not exhibit cytotoxicity and protected against L-DOPA (100 and 200 μM)-induced cell death. Gynosaponin TN-2 (0.5 and 1.0 μM) inhibited the L-DOPA (100 and 200 μM)-induced sustained extracellular signal-regulated protein kinases 1 and 2 phosphorylation. Gynosaponin TN-2 at 0.5 and 1.0 μM also reduced L-DOPA (100 and 200 μM)-induced JNK1/2 phosphorylation and cleaved caspase-3 expression. These results suggested that gynosaponin TN-2 exerts protective effects on L-DOPA (100 and 200 μM)-induced apoptotic cell death by modulating extracellular signal-regulated protein kinases 1 and 2 activation in pheochromocytoma 12 cells.|
|Molecules, 2010 Apr 16;15(4):2814-24 |
|Neuroprotective effects of herbal ethanol extracts from Gynostemma pentaphyllum in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease[Pubmed: 20428081]|
|6-Hydroxydopamine administration for 28 days (8 microg/2 microL) reduced the number of tyrosine hydroxylase (TH)-immunopositive neurons to 40.2% in the substantia nigra compared to the intact contralateral side. Dopamine, 3,4-dihydroxyphenylacetic acid, homovanillic acid and norepinephrine levels were reduced to 19.1%, 52.3%, 47.1% and 67.4% in the striatum of 6-hydroxydopamine-lesioned rats compared to the control group, respectively. However, an oral administration of herbal ethanol extracts from Gynostemma pentaphyllum (GP-EX) (10 mg/kg and 30 mg/kg) starting on day 3 post-lesion for 28 days markedly ameliorated the reduction of TH-immunopositive neurons induced by 6-hydroxydopamine-lesioned rat brain from 40.2% to 67.4% and 75.8% in the substantia nigra. GP-EX administration (10 and 30 mg/kg) also recovered the levels of dopamine, 3,4-dihydroxyphenylacetic acid, homovanillic acid and norepinephrine in post-lesion striatum to 64.1% and 65.0%, 77.9% and 89.7%, 82.6% and 90.2%, and 88.1% and 89.2% of the control group. GP-EX at the given doses did not produce any sign of toxicity such as weight loss, diarrhea and vomiting in rats during the 28 day treatment period and four gypenoside derivatives, gynosaponin TN-1, gynosaponin TN-2, gypenoside XLV and gypenoside LXXIV were identified from GP-EX. These results suggest that GP-EX might be helpful in the prevention of Parkinson's disease.|
Gynosaponin TN2 Description
||The herbs of Gynostemma pentaphyllum
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.