Science | Nature | Cell | View More
Natural Products
Uralenol
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Uralenol
Price:
CAS No.: 139163-15-8
Catalog No.: CFN91980
Molecular Formula: C20H18O7
Molecular Weight: 370.35 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The roots of Glycyrrhiza uralensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Biotech R&D Institute (USA)
  • Copenhagen University (Denmark)
  • Leibniz-Institut für Pflanzenb... (Germany)
  • Aarhus University (Denmark)
  • Chiang Mai University (Thailand)
  • Charles University in Prague (Czech Republic)
  • Universidad de Ciencias y Artes... (Mexico)
  • Sri Sai Aditya Institute of Pha... (India)
  • Universidad de Antioquia (Colombia)
  • University Medical Center Mainz (Germany)
  • Kamphaengphet Rajabhat University (Thailand)
  • More...
Package
Featured Products
Luteolin-4'-O-glucoside

Catalog No: CFN93776
CAS No: 6920-38-3
Price: $ / mg
Polyphyllin II

Catalog No: CFN99953
CAS No: 76296-72-5
Price: $/mg
Taraxasterol acetate

Catalog No: CFN97104
CAS No: 6426-43-3
Price: $/mg
Sagittatoside A

Catalog No: CFN90139
CAS No: 118525-35-2
Price: $318/5mg
Schizandrin C

Catalog No: CFN99708
CAS No: 61301-33-5
Price: $128/20mg
Pseudoaspidin

Catalog No: CFN90684
CAS No: 478-28-4
Price: $138/20mg
Paeonol

Catalog No: CFN98926
CAS No: 552-41-0
Price: $30/20mg
Schisantherin D

Catalog No: CFN96704
CAS No: 64917-82-4
Price: $ / mg
Ginkgolide A

Catalog No: CFN99638
CAS No: 15291-75-5
Price: $40/20mg
Cyanidin-3-O-galactoside chloride

Catalog No: CFN92040
CAS No: 27661-36-5
Price: $318/10mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Uralenol significantly shows the inhibitory activities against the PTP1B enzyme; it also shows inhibitory activities on mushroom tyrosinase using l-tyrosine as substrate(IC50 =49.5 uM). Uralenol shows potent anti-proliferation effects on ER-positive breast cancer MCF-7 cells in vitro.
Targets: Tyrosinase | Estrogen receptor | Progestogen receptor | PTP1B
In vitro:
Food Chemistry, 2008, 106(2):529-535.
Tyrosinase inhibitors from paper mulberry (Broussonetia papyrifera)[Reference: WebLink]

METHODS AND RESULTS:
Fractionation of a chloroform-soluble extract from twigs of Broussonetia papyrifera, led to the isolation of one new compound, 3,5,7,4′-tetrahydroxy-3′-(2-hydroxy-3-methylbut-3-enyl)flavone (1), and 10 known compounds, Uralenol (2), quercetin (3), isolicoflavonol (4), papyriflavonol A (5), broussoflavonol F (6), 5,7,3′,5′-tetrahydroxyflavanone (7), luteolin (8), isoliquiritigenin (9), broussochalcone A (10) and 5,7,3′,4′-tetrahydroxy-3-methoxyflavone (11). Their structures were identified by interpretation of MS, 1H NMR, 13C NMR, HMQC and HMBC data.
CONCLUSIONS:
Their inhibitory activities on mushroom tyrosinase using l-tyrosine as substrate were investigated and the IC50 values of 3,5,7,4′-tetrahydroxy-3′-(2-hydroxy-3-methylbut-3-enyl)flavone, Uralenol, quercetin and broussoflavonol F were found to be 96.6, 49.5, 57.8, and 82.3 μM, respectively, better than arbutin, a well-known tyrosinase inhibitor.
Phytochemistry Letters, 2013, 6(3):331-336.
Prenylflavone derivatives from Broussonetia papyrifera, inhibit the growth of breast cancer cells in vitro and in vivo[Reference: WebLink]
Two new prenylflavones 5,7,3′,4′-tetrahydroxy-3-methoxy-8-geranylflavone (1) and 5,7,3′,4′-tetrahydroxy-3-methoxy-8,5′-diprenylflavone (2), as well as four known ones, Uralenol (3), papyriflavonol A (4), broussoflavonol B (5) and broussochalcone A (6) were isolated and purified from an ethyl acetate-soluble extract of the barks of Broussonetia papyrifera.
METHODS AND RESULTS:
Their structures were determined with the spectroscopic methods including HR-EI-MS, 1D and 2D NMR. We found that compounds 2–6 showed potent anti-proliferation effects on ER-positive breast cancer MCF-7 cells in vitro. The IC50 values of compounds 2 and 5 were 4.41 and 4.19 μM respectively after the treatment of 72 h. We also found that compounds 2 and 5 strongly down-regulated expression concentrations of estrogen receptor-α (ER-α) and were able to inhibit tumor growth in a xenograft model of the human breast cancer line BCAP-37 in vivo.
CONCLUSIONS:
Our results demonstrated that prenylflavones from B. Papyrifera exhibit potent anti-tumor activity.
Uralenol Description
Source: The roots of Glycyrrhiza uralensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
3'-Hydroxymirificin

Catalog No: CFN95102
CAS No: 168035-02-7
Price: $338/5mg
Euphorbia factor L24

Catalog No: CFN95334
CAS No: 1613700-13-2
Price: $318/5mg
Isoeuphorbetin

Catalog No: CFN95207
CAS No: 50677-55-9
Price: $318/5mg
9,11-Dehydro-beta-boswellic acid

Catalog No: CFN95335
CAS No: 471-65-8
Price: $318/5mg
Ternatumoside II

Catalog No: CFN95366
CAS No: 1473419-87-2
Price: $318/5mg
6-Methoxyfraxinellone

Catalog No: CFN95485
CAS No: N/A
Price: $318/10mg
Polygalin J

Catalog No: CFN95175
CAS No: N/A
Price: $318/5mg
Atractylochromene

Catalog No: CFN95162
CAS No: 203443-33-8
Price: $318/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7001 mL 13.5007 mL 27.0015 mL 54.003 mL 67.5037 mL
5 mM 0.54 mL 2.7001 mL 5.4003 mL 10.8006 mL 13.5007 mL
10 mM 0.27 mL 1.3501 mL 2.7001 mL 5.4003 mL 6.7504 mL
50 mM 0.054 mL 0.27 mL 0.54 mL 1.0801 mL 1.3501 mL
100 mM 0.027 mL 0.135 mL 0.27 mL 0.54 mL 0.675 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Bioorg Med Chem Lett. 2002 Dec 2;12(23):3387-90.
Natural PTP1B inhibitors from Broussonetia papyrifera.[Pubmed: 12419367]

METHODS AND RESULTS:
Two new compounds, 8-(1,1-dimethylallyl)-5'-(3-methylbut-2-enyl)-3',4',5,7-tetrahydroxyflanvonol (1), 3'-(3-methylbut-2-enyl)-3',4',7-trihydroxyflavane (2) and three known compounds 3,3',4',5,7-pentahydroxyflavone (3), Uralenol (4), broussochalcone A (5) were isolated from the roots of Broussonetia papyrifera, and their structures determined by spectroscopic methods.
CONCLUSIONS:
Compounds 1, 3, 4 and 5 significantly show the inhibitory activities against the PTP1B enzyme.
Luteolin-4'-O-glucoside

Catalog No: CFN93776
CAS No: 6920-38-3
Price: $ / mg
Polyphyllin II

Catalog No: CFN99953
CAS No: 76296-72-5
Price: $/mg
Taraxasterol acetate

Catalog No: CFN97104
CAS No: 6426-43-3
Price: $/mg
Sagittatoside A

Catalog No: CFN90139
CAS No: 118525-35-2
Price: $318/5mg
Schizandrin C

Catalog No: CFN99708
CAS No: 61301-33-5
Price: $128/20mg
Pseudoaspidin

Catalog No: CFN90684
CAS No: 478-28-4
Price: $138/20mg
Paeonol

Catalog No: CFN98926
CAS No: 552-41-0
Price: $30/20mg
Schisantherin D

Catalog No: CFN96704
CAS No: 64917-82-4
Price: $ / mg
Ginkgolide A

Catalog No: CFN99638
CAS No: 15291-75-5
Price: $40/20mg
Cyanidin-3-O-galactoside chloride

Catalog No: CFN92040
CAS No: 27661-36-5
Price: $318/10mg
Tags: buy Uralenol | Uralenol supplier | purchase Uralenol | Uralenol cost | Uralenol manufacturer | order Uralenol | Uralenol distributor