Hederagenin 3-O-(2-O-acetyl-alpha-L-arabinopyranoside) | CAS:87562-05-8

Hederagenin 3-O-(2-O-acetyl-alpha-L-arabinopyranoside)

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Description:

Hederagenin 3-O-(2-O-acetyl-α-L-arabinopyranoside) significantly increased alkaline phosphatase (ALP) activity and the level of protein expression of bone sialoprotein (BSP) and osteocalcin (OC) .

In vitro:

Biosci Biotechnol Biochem . 2011;75(1):13-19.

Effects of the dichloromethane fraction of Dipsaci Radix on the osteoblastic differentiation of human alveolar bone marrow-derived mesenchymal stem cells[Pubmed: 21228489]

Dipsaci Radix is the dried root of Dipsacus asper Wall. It has been used in Korean herbal medicine to treat bone fractures. In this study, we examined the effect of the dichloromethane fraction of Dipsaci Radix (DR(DM)) on the osteoblastic differentiation of human alveolar bone marrow-derived MSCs (ABM-MSCs). The ABM-MSCs were isolated from healthy subjects and cultured in vitro, followed by phenotypic characterization. They showed a fibroblast-like morphology and expressed CD29, CD44, CD73, and CD105, but not CD34. Calcified nodules were generated in response to both dexamethasone (DEX) and DR(DM). There was a significant increase in the alkaline phosphatase (ALP) activity and protein expression of bone sialoprotein (BSP) and osteocalcin (OC) in response to DEX and DR(DM) as compared to control. These results provide evidence for the osteogenic potential of cultured ABM-MSCs in response to DR(DM). Also, an active single compound was additionally isolated from DR(DM). The single compound (hederagenin 3-O-(2-O-acetyl)-α-L-arabinopyranoside) also significantly increased ALP activity and the level of protein expression of BSP and OC. These results highlight the possible clinical applications of DR(DM) and hederagenin 3-O-(2-O-acetyl)-α-L-arabinopyranoside in bone regeneration.

Hederagenin 3-O-(2-O-acetyl-alpha-L-arabinopyranoside) Description

Source:	The herbs of Caulophyllum robustum
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

CAS No.	87562-05-8	Price	$318 / 10mg
Catalog No.	CFN95355	Purity	>=98%
Molecular Weight	646.9	Type of Compound	Triterpenoids
Formula	C₃₇H₅₈O₉	Physical Description	Powder
Download	COA MSDS	Similar structural	Comparison (Web) (SDF)

Product Name	Hederagenin 3-O-(2-O-acetyl-alpha-L-arabinopyranoside)
CAS No.:	87562-05-8
Catalog No.:	CFN95355
Molecular Formula:	C₃₇H₅₈O₉
Molecular Weight:	646.9 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The herbs of Caulophyllum robustum
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Price:	$318 / 10mg
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Triterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.5458 mL	7.7292 mL	15.4583 mL	30.9167 mL	38.6458 mL
5 mM	0.3092 mL	1.5458 mL	3.0917 mL	6.1833 mL	7.7292 mL
10 mM	0.1546 mL	0.7729 mL	1.5458 mL	3.0917 mL	3.8646 mL
50 mM	0.0309 mL	0.1546 mL	0.3092 mL	0.6183 mL	0.7729 mL
100 mM	0.0155 mL	0.0773 mL	0.1546 mL	0.3092 mL	0.3865 mL

CFN90430	Kalopanaxsaponin H	128730-82-5	913.09	C₄₇H₇₆O₁₇
CFN80305	Pulchinenoside E1	146100-02-9	1075.25	C₅₃H₈₆O₂₂
CFN95353	Dipsacussaponin C	152406-43-4	1353.5	C₆₄H₁₀₄O₃₀
CFN80362	Pulchinenoside E2	244202-36-6	1059.24	C₅₃H₈₆O₂₁
CFN94827	Dipsacobioside	123350-57-2	750.96	C₄₁H₆₆O₁₂
CFN90727	Methyl gypsogenin 3-O-beta-D-glucuronopyranoside	96553-02-5	660.9	C₃₇H₅₆O₁₀
CFN90996	Bayogenin 3-O-beta-D-glucopyranoside	104513-86-2	650.84	C₃₆H₅₈O₁₀
CFN98157	Tenuifolin	20183-47-5	680.37	C₃₆H₅₆O₁₂
CFN90659	Raddeanoside 20	335354-79-5	913.1	C₄₇H₇₆O₁₇
CFN99983	Ciwujianoside B	114902-16-8	1189.35	C₅₈H₉₂O₂₅