Anemoside A3 | CAS:129724-84-1 | Manufacturer ChemFaces

Anemoside A3

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $33.5 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Featured Products

More...

Isorhynchophylline

Catalog No: CFN96197
CAS No: 6859-01-4
Price: $138/20mg

Swertiajaponin

Catalog No: CFN90652
CAS No: 6980-25-2
Price: $218/10mg

Zederone

Catalog No: CFN92616
CAS No: 7727-79-9
Price: $278/20mg

Angeloylgomisin H

Catalog No: CFN90710
CAS No: 66056-22-2
Price: $238/10mg

Senkyunolide A

Catalog No: CFN99594
CAS No: 62006-39-7
Price: $90/20mg

Cauloside A

Catalog No: CFN96440
CAS No: 17184-21-3
Price: $318/10mg

(+)-Lyoniresinol 9'-O-glucoside

Catalog No: CFN97964
CAS No: 87585-32-8
Price: $318/10mg

Cyanidin-3-O-galactoside chloride

Catalog No: CFN92040
CAS No: 27661-36-5
Price: $318/10mg

Silychristin

Catalog No: CFN90243
CAS No: 33889-69-9
Price: $218/20mg

Aloin B

Catalog No: CFN90434
CAS No: 28371-16-6
Price: $138/20mg

Description:

Anemoside A3 is an attractive candidate for further development as a cognitive enhancer capable of alleviating memory dysfunctions associated with aging and neurodegenerative diseases. Anemoside A3 also produces relaxation in rat renal arteries through multiple mechanisms.

Targets:

NMDAR | Calcium Channel | Potassium Channel

In vitro:

Neuropsychopharmacology. 2015 Jul;40(8):1877-87.

Anemoside A3 Enhances Cognition through the Regulation of Synaptic Function and Neuroprotection.[Pubmed: 25649278]

Compounds that have the ability to both strengthen synaptic function and facilitate neuroprotection are valuable cognitive enhancers that may improve health and quality of life, as well as retard age-related cognitive deterioration. Medicinal plants are an abundant source of potential cognitive enhancers.
METHODS AND RESULTS:
Here we report that Anemoside A3 (AA3) isolated from Pulsatilla chinensis modulates synaptic connectivity in circuits central to memory enhancement. Anemoside A3 specifically modulates the function of AMPA-type glutamate receptors (AMPARs) by increasing serine phosphorylation within the GluA1 subunit, which is a modification required for the trafficking of GluA1-containing AMPARs to synapses. Furthermore, Anemoside A3 administration activates several synaptic signaling molecules and increases protein expressions of the neurotrophin brain-derived neurotrophic factor and monoamine neurotransmitters in the mouse hippocampus. In addition to acting through AMPARs, Anemoside A3 also acts as a non-competitive NMDA receptor (NMDAR) modulator with a neuroprotective capacity against ischemic brain injury and overexcitation in rats. These findings collectively suggest that AA3 possesses a unique ability to modulate the functions of both AMPARs and NMDARs. Concordantly, behavioral studies indicate that AA3 not only facilitates hippocampal long-term potentiation but also enhances spatial reference memory formation in mice.
CONCLUSIONS:
These multifaceted roles suggest that Anemoside A3 is an attractive candidate for further development as a cognitive enhancer capable of alleviating memory dysfunctions associated with aging and neurodegenerative diseases.

Planta Med. 2003 Feb;69(2):171-4.

Pulsatilloside A and anemoside A3 protect PC12 cells from apoptosis induced by sodium cyanide and glucose deprivation.[Pubmed: 12624827]

METHODS AND RESULTS:
Using sodium cyanide (NaCN) and glucose deprivation induced cell injury in PC12 as an injury model, we investigated the protective effects of pulsatilloside A and anemoside A 3 on neurons. The results showed that PC12 cells under the NaCN-injury and glucose deprivation would undergo apoptosis. Additions of pulsatilloside A and anemoside A 3, at dosages ranging from 0.1, 1 and 10 microg/ml, protected PC12 cells from apoptosis determined by MTT, LDH release analysis, and flow cytometry measurement.

Anemoside A3 Description

Source:	The roots of Pulsatilla chinensis.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Planta Med. 2010 Nov;76(16):1814-9.

Anemoside A3-induced relaxation in rat renal arteries: role of endothelium and Ca2+ channel inhibition.[Pubmed: 20506075]

Anemoside A3, a lupane-type triterpenoid saponin, exists in the roots of Pulsatilla chinensis, but its pharmacological properties are largely unknown.
METHODS AND RESULTS:
The present study aimed to investigate the mechanisms underlying Anemoside A3 induced relaxation in rat renal arteries. Changes of isometric force were determined on arteries with a myograph. Anemoside A3 caused concentration-dependent relaxation in precontracted aortas, mesenteric, left coronary, and renal arteries. Removal of endothelium or treatment with charybdotoxin plus apamin slightly but significantly attenuated the relaxation in renal arteries. TEA(+) inhibited the relaxation caused by Anemoside A3 in renal arteries with and without endothelium while glibenclamide, BaCl(2), or capsaicin had no effect on it. Anemoside A3 produced less relaxation in rings contracted by 60 mM KCl compared with rings contracted by receptor-dependent constrictors. It further inhibited contractions induced by Ca(2+) influx through nifedipine-sensitive voltage-gated Ca(2+) channels, nifedipine-insensitive receptor-operated Ca(2+) channels, and by intracellular Ca(2+) release. Pretreatment with nifedipine attenuated Anemoside A3-induced relaxation.
CONCLUSIONS:
Taken together, the present results indicate that Anemoside A3 produces relaxation in rat renal arteries through multiple mechanisms. The release of CTX/apamin-sensitive endothelium-derived hyperpolarizing factor, stimulation of TEA(+)-sensitive K(+) channel, and inhibition of Ca(2+) influx jointly contribute to the relaxation.

Product Name	Anemoside A3
Price:	$80 / 20mg
CAS No.:	129724-84-1
Catalog No.:	CFN90182
Molecular Formula:	C₄₁H₆₆O₁₂
Molecular Weight:	750.96 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The roots of Pulsatilla chinensis.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-Parkinson Compound Library Triterpenoids Compound Library Potassium Channel Inhibitor Library NMDAR Inhibitor Library Calcium Channel Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.3316 mL	6.6581 mL	13.3163 mL	26.6326 mL	33.2907 mL
5 mM	0.2663 mL	1.3316 mL	2.6633 mL	5.3265 mL	6.6581 mL
10 mM	0.1332 mL	0.6658 mL	1.3316 mL	2.6633 mL	3.3291 mL
50 mM	0.0266 mL	0.1332 mL	0.2663 mL	0.5327 mL	0.6658 mL
100 mM	0.0133 mL	0.0666 mL	0.1332 mL	0.2663 mL	0.3329 mL

CFN92092	2alpha-hydroxy-3beta-acetyloxy-betulic acid	1163728-89-9	514.8	C₃₂H₅₀O₅
CFN98305	3,27-Dihydroxy-20(29)-lupen-28-oic acid methyl ester	263844-79-7	486.7	C₃₁H₅₀O₄
CFN98306	3-Acetoxy-27-hydroxy-20(29)-lupen-28-oic acid methyl ester	263844-80-0	528.8	C₃₃H₅₂O₅
CFN90310	Anemosapogenin	85999-40-2	472.71	C₃₀H₄₈O₄
CFN90182	Anemoside A3	129724-84-1	750.96	C₄₁H₆₆O₁₂
CFN80453	Pulsatilla saponin D	848784-85-0	913.10	C₄₇H₇₆O₁₇
CFN94819	Pulchinenoside B	135247-95-9	1075.25	C₅₃H₈₆O₂₂
CFN99786	Anemoside B4	129741-57-7	1221.38	C₅₉H₉₆O₂₆
CFN80291	Pulchinenoside E	366814-43-9	1383.534	C₆₅H₁₀₆O₃₁
CFN96240	3alpha-Acetoxy-20-oxo-29-norlupane-23,28-dioic acid	262272-76-4	530.7	C₃₁H₄₆O₇