ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $536.9 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Nat Prod Commun.2014, 9(5):679-82Sci Rep.2015, 5:13194University of Limpopo2016, 1-237Plant Cell,Tissue & Organ Culture...2016...Kor. J. Pharmacogn.2016, 47(1):62-72J Exp Bot.2016, 67(12):3777-88Org Biomol Chem.2017, 15(31):6483-6492J Ethnopharmacol.2017, 198:205-213
Nutrients.2018, 10(12)International Food Research Journ...2018...Korean J Dent Mater.2018, 45(2):139-146Eur J Pharmacol.2018, 832:96-103J Sci Food Agric.2018, 98(3):1153-1161Nat Commun.2019, 10(1):5169Enzyme Microb Technol.2019, 122:64-73Molecules.2019, 24(24),4583
J Ethnopharmacol.2019, 241:112025Phytother Res.2019, 33(5):1490-1500Chin J Pharm Anal.2019, 39(7):1217-1228Int J Cosmet Sci.2019, 41(1):12-20Chemistry of Natural Compounds...2019...Phytomedicine.2019, 57:95-104J Mater Chem B.2019, 7(39):5896-5919
Our products had been exported to the following research institutions and universities, And still growing.
Deutsches Krebsforschungszentrum (Germany)Ateneo de Manila University (Philippines)Vin?a Institute of Nuclear Scie... (Serbia)Macau University of Science and... (China)
Siksha O Anusandhan University (India)Kamphaengphet Rajabhat University (Thailand)University of Limpopo (South Africa)Istanbul University (Turkey)
Universitas islam negeri Jakarta (Indonesia)Universiti Putra Malaysia(UPM) (Malaysia)FORTH-IMBB (Greece)
Related Screening Libraries
|| Cauloside A exhibits concentration- and time-dependent mitochondriotoxic activities. |
|J Nat Prod. 2014 Jan 24;77(1):111-7. |
|Toxins in botanical dietary supplements: blue cohosh components disrupt cellular respiration and mitochondrial membrane potential.[Pubmed: 24328138 ]|
|Certain botanical dietary supplements have been associated with idiosyncratic organ-specific toxicity. Similar toxicological events, caused by drug-induced mitochondrial dysfunction, have forced the withdrawal or U.S. FDA "black box" warnings of major pharmaceuticals. |
METHODS AND RESULTS:
To assess the potential mitochondrial liability of botanical dietary supplements, extracts from 352 authenticated plant samples used in traditional Chinese, Ayurvedic, and Western herbal medicine were evaluated for the ability to disrupt cellular respiration. Blue cohosh (Caulophyllum thalictroides) methanol extract exhibited mitochondriotoxic activity. Used by some U.S. midwives to help induce labor, blue cohosh has been associated with perinatal stroke, acute myocardial infarction, congestive heart failure, multiple organ injury, and neonatal shock. The potential link between mitochondrial disruption and idiosyncratic herbal intoxication prompted further examination. The C. thalictroides methanol extract and three saponins, Cauloside A (1), saponin PE (2), and cauloside C (3), exhibited concentration- and time-dependent mitochondriotoxic activities. Upon treatment, cell respiration rate rapidly increased and then dramatically decreased within minutes.
Mechanistic studies revealed that C. thalictroides constituents impair mitochondrial function by disrupting membrane integrity. These studies provide a potential etiological link between this mitochondria-sensitive form of cytotoxicity and idiosyncratic organ damage.
Cauloside A Description
||The herbs of Caulophyllum robustum
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Zhong Yao Cai. 2012 Nov;35(11):1789-92. |
|Chemical constituents of Dipsacus asper.[Pubmed: 23627090]|
|To study the chemical constituents of Dipsacus asper.
METHODS AND RESULTS:
Column chromatography on Silica gel and RP-C18 were applied for isolation and purification of the constituents. Their structures were identified by spectral and chemical methods.
From the crude MeOH fraction of Dipsacus asper, 12 compounds were isolated and identified as Sucrose (1), beta-sitosterol (2), Oleanic acid (3), Triplostoside A (4), Loganin (5), Loganin acid (6), Sweroside (7), Epi-vogeloside ( 8), Vogeloside (9), Akebiasaponin D(10), Cauloside A(11),7-Deoxyloganic acid (12).
Compounds 8, 9, 12 are isolated from this plant for the first time.