1. Vanillic acid is a potent free radical scavenger, thus, it exerts protective effects in isoproterenol induced cardiotoxic rats due to its free radical scavenging, antioxidant and anti-inflammatory properties.
2. Vanillic acid has inhibitory effect on methylglyoxal-mediated glycation in apoptotic Neuro-2A cells.
3. Vanillic acid has hepatoprotective effect on CCl4-induced liver injury.
4. Vanillic acid prevents altered ion pumps, ions and inhibited Fas-receptor and caspase mediated apoptosis-signaling pathway and cardiomyocyte death in isoproterenol induced myocardial infarcted rats.
1. Carnosic acid can protect neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1.
2. Carnosic acid has antioxidant properties, it is a powerful inhibitor of lipid peroxidation in microsomal and liposomal systems.
3. Carnosic acid, vitamin C, and vitamin E show photoprotective potential.
4. Carnosic acid is a class of lipid absorption inhibitor from sage.
5.. Carnosic acid is capable of antiproliferative action in leukemic cells and can cooperate with other natural anticancer compounds in growth-inhibitory and differentiating effects.
6. Carnosic acid has a protective effect on cisplatin induced experimental nephrotoxicity and is attributed to its potent antioxidant and antiapoptotic properties.
7. Carnosic acid has antimicrobial activity against oral pathogens.
8. Carnosic acid can inhibit adipogenesis in vitro, and it is a therapeutic agent for obesity-related non-alcoholic fatty liver disease.
|CFN99120||Isochlorogenic acid C
1. Isochlorogenic acid C has antioxidant activity.
1. Calycosin-7-O-β-d-glucoside can protect BBB integrity in experimental cerebral ischemia–reperfusion injury via regulating NO/cav-1/MMPs pathway.
2. Calycosin-7-O-β-D-glucoside can promote oxidative stress-induced cytoskeleton reorganization through integrin-linked kinase signaling pathway in vascular endothelial cells.
3. Calycosin-7-O-β-d-glucoside attenuates ischemia-reperfusion injuryin vivovia activation of the PI3K/Akt pathway.
4. Calycosin-7-O-β-D-glucoside has effects on cell apoptosis in cervical cancer HeLa cells and expression of Bcl-2/Bax.
1. Liquiritin can increase SOD activity, inhibit lipid peroxidation, and lessen production of MDA, demonstrates that a potential antidepressant-like effect of liquiritin treatment on chronic variable stress can induce depression model rats, which might be related to defense of liquiritin against oxidative stress.
2. Liquiritin has neuroprotective effect against focal cerebral ischemia/reperfusion in mice via its antioxidant and antiapoptosis properties, it may be a potential agent against cerebral I/R injury in mice.
3. Liquiritin significantly promotes the neurite outgrowth stimulated by NGF in PC12 cells in dose dependant manners , it may be a good candidate for treatment of various neurodegenerative diseases such as Alzheimer’s disease or Parkinson’s disease.
4. Liquiritin can attenuate advanced glycation end products-induced endothelial dysfunction via RAGE/NF-κB pathway in human umbilical vein endothelial cells, it may be a promising agent for the treatment of vasculopathy in diabetic patients.