1. Astragaloside III can effectively reduce cancer cell survival in vitro and inhibit the tumor growth in vivo, the potential mechanism is the induction of cell apoptosis signaling pathways, suggests that it provides a new therapeutic tool to treat breast cancer.
2. Astragaloside III, ononin and astragalosideIV have anti-gastric ulcer effects, also exhibit strong growth-promoting effects in cultured GES-1 cells.
1. Bisdemethoxycurcumin can regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism, also suppresses MCF-7 cells proliferation by inducing ROS accumulation and modulating senescence-related pathways.
2. Bisdemethoxycurcumin directly accelerates gastric ulcer healing with potency equal to curcumin, its antiulcer effect might be due to its properties of decreasing gastric acid secretion and enhancing the mucosal defensive mechanism through suppression of iNOS-mediated inflammation.
3. Bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of MMPs and uPA.
4. Bisdemethoxycurcumin induces apoptosis in activated HSCs, but not in hepatocytes, by impairing cellular energetics and causing a downregulation of cytoprotective proteins, likely through a mechanism that involves CBR2.
5. Bisdemethoxycurcumin has effects on 12-Ο-tetradecanoylphorbol-13-acetate-induced tumor promotion.
6. Bisdemethoxycurcumin has antioxidant activities, inhibits ovarian cancer via reducing oxidative stress mediated MMPs expressions.
1. Coumarin is an edema modifier in clinical medical treatment.
2. Coumarin has appetite-suppressing properties, which in plants may reduce the impact of grazing animals.
3. Coumarin is also used as a gain medium in some dye lasers, and as a sensitizer in older photovoltaic technologies.
4. Coumarin is used in the pharmaceutical industry as a precursor reagent in the synthesis of a number of synthetic anticoagulant pharmaceuticals similar to dicoumarol.
1. Naringin inhibits some drug-metabolizing cytochrome P450 enzymes, including CYP3A4 and CYP1A2, which may result in drug-drug interactions.
2. Naringin has protective effects against cognitive dysfunction and reduces diabetes-induced neuropathy in rats.
3. Naringin is an inhibitor of vascular endothelial growth factor (VEGF) release, which causes angiogenesis.
4. Naringin has antioxidant properties in its cardioprotective effects in various models, by providing cardioprotection by inducing the phosphorylation of ERK1/2, PKCδ, and AKT, which subsequently activated Nrf2 and its downstream genes.
1. Marmin and nobiletin are ascribed primarily to the maintenance of the mucosal barrier integrity and inhibition of gastric motor activity and secondarily due to the prevention of the effects of endogenous acetylcholine and histamine.
2. Marmin could inhibit contraction of the guinea-pig tracheal smooth muscle, especially by interfering histamine receptor, inhibiting the histamine release from mast, inhibiting intracellular Ca(2+) release from the intracellular store and the Ca(2+) influx through voltage-dependent Ca(2+) channels.