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  • Bioactive Products
    Catalog No. Information
    CFN99184 Artemether

    1. Artemether has significant anticancer and antitumor activities.
    2. Artemether is an anti-schistosomiasis agent.
    3. Artemether is an antimalarial agent.
    4. Artemether and arteether have fatal neurotoxicity.
    CFN99748 (+)-Bicuculline

    1. (+)-Bicuculline is GABAA-receptor antagonist.
    2. (+)-Bicuculline is a kind of convulsant.
    CFN98289 Tutin

    1. Tutin has human effect on CNS from ingestion of C. spp .
    CFN90044 Corticosterone

    1. Corticosterone is considered to be a stress hormone and to be cytotoxic toward neurons, and the cytotoxic effect could be protected by Yokukansan.
    2. A delayed effect of elevated Corticosterone on breeding success rather than an immediate suppression of prolactin concentrations causing premature failure.
    CFN98590 Rotenone

    1. Rotenone is a mitochondrial complex I inhibitor that produces an animal model of Parkinson's disease.
    2. Rotenone-induced α-synuclein aggregation is mediated by the calcium/GSK3β signaling pathway.
    3. SiRNA-mediated GAPDH knockdown reduced Rotenone-induced H9C2 cell death occurring via autophagy and anti-oxidative stress pathway.
    4. Rotenone can increase intracellular levels of the toxic dopamine metabolite 3,4-dihydroxyphenyl-acetaldehyde (DOPAL), via decreasing DOPAL metabolism by aldehyde dehydrogenase (ALDH) and decreasing vesicular sequestration of cytoplasmic dopamine by the vesicular monoamine transporter (VMAT).