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    Natural Products
    1,3,9-Trimethyluric acid
    1,3,9-Trimethyluric acid
    Information
    CAS No. 7464-93-9 Price
    Catalog No.CFN89099Purity>=98%
    Molecular Weight210.19Type of CompoundAlkaloids
    FormulaC8H10N4O3Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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  • Biological Activity
    Description: 1,3,9-Trimethyluric acid exhibits in vitro cytotoxic activity against breast cancer (MCF-7), human neuroblastoma (SHSY5Y), human non-small cell lung cancer (A549) and human liver cancer (HEPG2) with IC50 value in the range of 1-3 uM. 1,3,9-Trimethyluric acid also shows promising anti-inflammatory effects in LPS induced murine macrophage J774 in vitro models in the concentration range of 100-1000 nM.
    Targets: Immunology & Inflammation related
    In vitro:
    Int.J.Sci. Res.,2017,6(1):13-17.
    Isolation and X-ray crystal structure of 1,3,9 trimethyl purine derivative having cytotoxic activities from marine sponge Amphimedon viridis (Duchassaing & Michelotti,1864) [Reference: WebLink]

    METHODS AND RESULTS:
    A new purine derivative 1,3,9-Trimethyluric acid (1) was isolated from the marine sponge Amphimedon viridis and structure were confirmed by X-ray crystallography data.
    CONCLUSIONS:
    Compound 1 exhibited in vitro cytotoxic activity against breast cancer (MCF-7), human neuroblastoma (SHSY5Y), human non-small cell lung cancer (A549) and human liver cancer (HEPG2) with IC50 value in the range of 1-3 μM and also showed promising anti-inflammatory effects in LPS induced murine macrophage J774 in vitro models in the concentration range of 100-1000 nM.
    1,3,9-Trimethyluric acid Description
    Source: The culture of the marine sponge Amphimedon viridis.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.7576 mL 23.788 mL 47.576 mL 95.152 mL 118.94 mL
    5 mM 0.9515 mL 4.7576 mL 9.5152 mL 19.0304 mL 23.788 mL
    10 mM 0.4758 mL 2.3788 mL 4.7576 mL 9.5152 mL 11.894 mL
    50 mM 0.0952 mL 0.4758 mL 0.9515 mL 1.903 mL 2.3788 mL
    100 mM 0.0476 mL 0.2379 mL 0.4758 mL 0.9515 mL 1.1894 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.