| Structure Identification: |
| Chinese Traditional and Herbal Drugs, 2014, 45(7):906-912. | | Chemical constituents from roots tubers of Serratula chinensis[Reference: WebLink] | To study the chemical constituents from the roots tubers of Serratula chinensis.
METHODS AND RESULTS:
The chemical constituents were separated and purified by silica gel, Sephadex LH-20, ODS column chromatographies, and preparative HPLC. Their structures were determined by physicochemical properties and spectral data. Sixteen compounds(ecdysteroids) were isolated from the n-butanol fraction of 95% ethanol extract in the root tubers of S. chinensis, and their structures were identified as 20-hydroxyecdysone(1), polypodine B(2), carthamosterone(3), 20-hydroxyecdysone-20, 22-monoacetonide(4), 24-epi-abutasterone(5), polypodine C(6), coronatasterone(7), 20-hydroxyecdysone 2-O-β-D-glucopyranoside(8), 20-hydroxyecdysone 25-O-β-Dglucopyranoside(9), polypodine B 20, 22-acetonide(10), shidasterone(11), 2-O-Acetyl-20-hydroxyecdysone(12), 3-O-acetyl-20-hydroxyecdysone(13), 20-hyderoxyecdysone-20, 22-butylidene acetal(14), 24-methylene-shidasterone(15), and ajugasterone D(16).
CONCLUSIONS:
Compounds 2, 4, 5, 7—10, 12, 15, and 16 are isolated from this plant for the first time, and compounds 5, 7—10, and 16 are found in the plants of genus Serratula L. for the first time. |
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