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    2''-O-Rhamnosylicariside II
    Information
    CAS No. 135293-13-9 Price $388 / 10mg
    Catalog No.CFN92551Purity>=98%
    Molecular Weight660.7Type of CompoundFlavonoids
    FormulaC33H40O14Physical DescriptionYellow powder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)
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    2''-O-Rhamnosylicariside II Description
    Source: The herbs of Epimedium brevicornu
    Biological Activity or Inhibitors: 1.2"-O-Rhamnosylicariside II shows potent inhibitory activities on osteoclast-like cell formation at a concentration of 2 uM without toxic effects.
    2. 2″-O-Rhamnosylicariside II shows potent antioxidant activity, with IC50 values of 11.5 ug/mL and 90.5 uM.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi:10.1016/j.phymed.2017.12.030

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5135 mL 7.5677 mL 15.1355 mL 30.2709 mL 37.8387 mL
    5 mM 0.3027 mL 1.5135 mL 3.0271 mL 6.0542 mL 7.5677 mL
    10 mM 0.1514 mL 0.7568 mL 1.5135 mL 3.0271 mL 3.7839 mL
    50 mM 0.0303 mL 0.1514 mL 0.3027 mL 0.6054 mL 0.7568 mL
    100 mM 0.0151 mL 0.0757 mL 0.1514 mL 0.3027 mL 0.3784 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    2''-O-Rhamnosylicariside II References Information
    Citation [1]

    Journal of Traditional Medicines, 2007, 24:19-23.

    Inhibitory effect of constituents of Bu-Shen-Jian-Gu-Tang on osteoclast-like cell formation[Reference: WebLink]
    Chemical investigation of these two fractions resulted in the isolation of 11 compounds, for which the structures were elucidated based on spectroscopic analysis and chemical reactions. The inhibitory activities of the isolated compounds on osteoclast-like cell formation were evaluated. Among the eleven compounds, icariin (1), icarisid II (2), 2''-O-Rhamnosylicariside II (3), kaempferol (8), chikusetsusaponin IVa (10) and chikusetsusaponin V (11) showed potent inhibitory activities at a concentration of 2 μM without toxic effects. The preventive effect of Bu-Shen-Jian-Gu-Tang on bone loss may be due to the inhibitory activities of these compounds.
    Citation [2]

    Natural Product Sciences, 2008, 14(4):233-8.

    Flavonol Glycosides with Antioxidant Activity from the Aerial Parts of Epimedium koreanum Nakai[Reference: WebLink]
    The aerial parts of Epimedium koreanum Nakai have been used to stimulate hormone secretion in treating impotence. Ten flavonol glycosides, 3,4,5-trihydroxy-8-prenylflavone 7-O-[β-D-glucopyranosyl(1 → 2)-β-D-glucopyranoside] (1), hyperoside (2), icarisid II (3), 2''-O-Rhamnosylicariside II (4), epimedin A (5), epimedin B (6), epimedin C (7), icariin (8), hexandraside E (9), and epimedoside A (10) were isolated from the an ethylacetate soluble extracts of the aerial parts of Epimedium koreanum Nakai through activity-monitord fractionation and isolation method. The structures of compounds 1 - 10 were elucidated by high resolution fast atom bombardment mass spectrometry and two dimentional nuclear magnetic resonance spectroscopy analysis. Compounds 1 and 4 showed potent antioxidant activity, with IC50 values of 19.7 and 11.5 μg/mL and 88.2 and 90.5 μM, respectively.