ChemFaces is a professional high-purity natural products manufacturer.
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Inflammation.2015, 38(4):1502-16University of Limpopo2016, 1777Mediators Inflamm.2016, 2016:7216912Mol Immunol. 2016, 78:121-132Korean Journal of Pharmacognosy...2017...Chem Pharm Bull (Tokyo)....2017...LWT-Food Science and Technology...2017...Front Immunol.2017, 8:1542
Front Pharmacol.2017, 8:673Oncotarget.2017, 9(3):4161-4172Neurochem Int.2018, 121:114-124J Ethnopharmacol.2018, 210:88-94J Sep Sci.2018, 41(9):1938-1946Korean Journal of Pharmacognosy...2018...The Japan Society for Analytical ...2018...J Nat Prod.2018, 81(4):966-975
Biomed Pharmacother.2019, 111:262-269Drug Invention Today...2019...Molecules.2019, 24(17):E3127Phytother Res.2019, 33(7):1784-1793Cell Physiol Biochem....2019...TCI CO.2019, US20190151281A1Pharmacological Reports2020, 1-9
Our products had been exported to the following research institutions and universities, And still growing.
Istanbul University (Turkey)Martin Luther University of Hal... (Germany)Instituto Politécnico de Bragan?a (Portugal)Korea Institute of Oriental Med... (Korea)
Universitas islam negeri Jakarta (Indonesia)The Ohio State University (USA)Mahatma Gandhi University (India)Uniwersytet Medyczny w ?odzi (Poland)
John Innes Centre (United Kingdom)Warszawski Uniwersytet Medyczny (Poland)Universidad de Buenos Aires (Argentina)
Related Screening Libraries
|| 3-Deoxysappanone B has vasorelaxation effects, it can mediate endothelium-
independent vasodilator action in rat thoracic aortic rings.|
|Zhongguo Zhong Yao Za Zhi. 2009 Mar;34(6):731-4. |
|Vasorelaxation effects of homoisoflavonoids from Caesalpinia sappan in rat thoracic aortic rings.[Pubmed: 19624017]|
|To identify and elucidate the vasorelaxant activity of homoisoflavonoids, the main chemical components from Lignum Sappan (the stems of Caesalpinia sappan), in isolated rat thoracic aortic rings pre-contracted with phenylephrine (PE, 1 micromol x L(-1)) and KCl (60 mmol x L(-1)).
METHODS AND RESULTS:
The tension of rat thoracic aorta rings was used to evaluated the vasorelaxant activities of four homoisoflavonoids, brazlin (1), (E)-3-(3,4-dihydroxybenzylidene)-7-hydroxychroman-4-one (2), sappanone B (3), 3-Deoxysappanone B (4).
Cumulative addition of homoisoflavonoids (2, 3 and 4) (50-1000 micromol x L(-1)) exhibited an acute relaxation either in endothelium-intact or endothelium-denuded rings in a concentration-dependent manner. However, this relaxation was significantly inhibited in endothelium-denuded condition and in the presence of endothelial nitric oxide synthase (eNOS) inhibitor, N(W)-nitro-L-arginine methyl ester (L-NNA, 100 micromol x L(-1)), and a soluble guanylate cylcase (sGC) inhibitor, methylene blue (MB, 10 micromol x L(-1)) when addition of variation homoisoflavonoids brazlin (1) (50-1000 micromol x L(-1)).
These results indicate that normo-homoisoflavonoids (2, 3 and 4) from Caesalpinia sappan mediates endothelium-independent vasodilator action in rat thoracic aortic rings, while the variation homoisoflavonoids brazlin elicits endothelium-dependent relaxation might via nitric oxide (NO)-cGMP pathway. This research could explain the pharmacological activities of homoisoflavonoids to a certain degree.
3-Deoxysappanone B Description
||The heartwoods of Caesalpinia sappan
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Molecules. 2008 Aug 28;13(8):1923-30. |
|A new 3-benzylchroman derivative from Sappan Lignum (Caesalpinia sappan).[Pubmed: 18794793]|
METHODS AND RESULTS:
3'-Deoxy-4-O-methylepisappanol, a new 3-benzylchroman derivative, was isolated from Sappan Lignum, together with thirteen known chemical compounds identified as protosappanin A, sappanchalcone, sappanone B, palmitic acid, (+)-(8S,8'S)-bisdihydrosiringenin, brazilein, 3-deoxysappanchalcone, (+)-lyoniresinol, 3-Deoxysappanone B, protosappanin B, isoprotosappanin B, 3'-O-methylbrazilin and brazilin, respectively.
Among these known compounds, this is the first time that (+)-(8S,8'S)-bisdihydrosiringenin was obtained from the family Caesalpiniaceae.