• ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Natural Products
    3-O-Methylquercetin
    Information
    CAS No. 1486-70-0 Price $313 / 5mg
    Catalog No.CFN99616Purity>=98%
    Molecular Weight316.3 Type of CompoundFlavonoids
    FormulaC16H12O7Physical DescriptionYellow powder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    Our products had been exported to the following research institutions and universities, And still growing.
  • Lodz University of Technology (Poland)
  • Universidade Federal de Goias (U... (Brazil)
  • Universit?t Basel (Switzerland)
  • Cornell University (USA)
  • Universitas Airlangga (Indonesia)
  • Julius Kühn-Institut (Germany)
  • Universidad Industrial de Santan... (Colombia)
  • Charles University in Prague (Czech Republic)
  • University of Malaya (Malaysia)
  • University of Queensland (Australia)
  • University of Oslo (Norway)
  • More...
  • Package
    Featured Products
    11-Keto-beta-boswellic acid

    Catalog No: CFN90152
    CAS No: 17019-92-0
    Price: $168/5mg
    Ayanin

    Catalog No: CFN96157
    CAS No: 572-32-7
    Price: $288/10mg
    (-)-Pinoresinol

    Catalog No: CFN92287
    CAS No: 81446-29-9
    Price: $268/5mg
    Enmein

    Catalog No: CFN92435
    CAS No: 3776-39-4
    Price: $433/5mg
    7-Methoxyneochamaejasmine A

    Catalog No: CFN92156
    CAS No: 402828-38-0
    Price: $433/5mg
    Biological Activity
    Description: 1. 3-O-Methylquercetin may exert its anti-inflammatory effect through the inhibition of iNOS DNA transcription.
    2. 3-O-Methylquercetin is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a low K(m) value.
    3. 3-O-Methylquercetin inhibits total cAMP- and cGMP-phosphodiesterase (PDE) of guinea pig trachealis at low concentrations.
    4. 3-O-Methylquercetin has both anti-inflammatory and bronchodilating effects, and has the potential for use in the treatment of asthma at a dose without affecting blood pressure.
    5. 3-O-Methylquercetin has antiviral activity.
    Targets: cAMP | PDE | IL Receptor | TNF-α | NOS | NO | Antifection
    3-O-Methylquercetin Description
    Source: The herbs of Croton cascarilloides
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Recent ChemFaces New Products and Compounds
    Sibiricaxanthone B

    Catalog No: CFN90644
    CAS No: 241125-81-5
    Price: $288/20mg
    Methylnissolin

    Catalog No: CFN90838
    CAS No: 733-40-4
    Price: $388/10mg
    20(21)-Dehydrolucidenic acid A

    Catalog No: CFN90829
    CAS No: 852936-69-7
    Price: $358/5mg
    Arjunic acid

    Catalog No: CFN98397
    CAS No: 31298-06-3
    Price: $413/5mg
    Glucoliquiritin

    Catalog No: CFN95011
    CAS No: 93446-18-5
    Price: $318/10mg
    Oroxylin A 7-O-beta-D-glucuronide

    Catalog No: CFN90191
    CAS No: 36948-76-2
    Price: $318/20mg
    3-Methoxyshancigusin I

    Catalog No: CFN95062
    CAS No: N/A
    Price: $413/5mg
    alpha-Viniferin

    Catalog No: CFN97068
    CAS No: 62218-13-7
    Price: $318/10mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi:10.1016/j.phymed.2017.12.030

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1616 mL 15.8078 mL 31.6156 mL 63.2311 mL 79.0389 mL
    5 mM 0.6323 mL 3.1616 mL 6.3231 mL 12.6462 mL 15.8078 mL
    10 mM 0.3162 mL 1.5808 mL 3.1616 mL 6.3231 mL 7.9039 mL
    50 mM 0.0632 mL 0.3162 mL 0.6323 mL 1.2646 mL 1.5808 mL
    100 mM 0.0316 mL 0.1581 mL 0.3162 mL 0.6323 mL 0.7904 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    3-O-Methylquercetin References Information
    Citation [1]

    Pharmazie. 2009 Nov;64(11):726-30.

    Development of topical nanoemulsions containing quercetin and 3-O-methylquercetin.[Pubmed: 20099516]
    This study describes the physico-chemical properties and the skin permeation profile of quercetin (Q) and 3-O-Methylquercetin (MQ) from lipid nanoemulsions. Formulations composed of octyldodecanol, egg lecithin, water (NE) and cetyl trimethyl ammonium bromide (CNE) were obtained by spontaneous emulsification. This procedure yielded monodisperse nanoemulsions exhibiting a mean droplet size of approximately 200-300 nm. Nanoemulsions were further characterized in terms of zeta-potential, surface tension, and morphology by transmission electron microscopy. The amount of flavonoids incorporated into nanoemulsions reached nearly 100% (at 1 mg/mL). The permeation studies were carried out using ear pig skin mounted in Franz diffusion cells. The overall results have shown a slow permeation profile of both Q and 3-O-Methylquercetin from nanoemulsions. However, a higher permeation flux rate of flavonoids from CNE (approximately 0.2 microg/cm2/h) as compared to NE (approximately 0.08 microg/cm2/h) was observed, showing the effect of the positively charged surface of CNE on this parameter. Such results open interesting perspectives for the topical administration of the flavonoids Q and 3-O-Methylquercetin.
    Citation [2]

    Planta Med. 2004 Dec;70(12):1123-7.

    Suppressive effects of 3-O-methylquercetin on ovalbumin-induced airway hyperresponsiveness.[Pubmed: 15643544]
    Rhamnus nakaharai Hayata (Rhamnaceae) has been used as a folk medicine in Taiwan for treating constipation, inflammation, tumors, and asthma. 3-O-Methylquercetin (3-MQ), a main constituent of the plant, has been reported to inhibit total cAMP- and cGMP-phosphodiesterase (PDE) of guinea pig trachealis at low concentrations. 3-O-Methylquercetin has been also reported to more selectively inhibit PDE3 than PDE4 with a low K(m) value. Therefore we were interested in investigating its suppressive effects on ovalbumin (OVA)-induced airway hyperresponsiveness in vivo and in vitro. 3-O-Methylquercetin (3-30 micromol/kg, i. p.) significantly suppressed the enhanced pause (Penh) value induced by aerosolized methacholine (50 mg/mL) in sensitized mice after secondary allergen challenge. 3-O-Methylquercetin (3-30 micromol/kg, i. p.) also significantly suppressed total inflammatory cells, macrophages, neutrophils, and eosinophils, but not lymphocytes. In addition, 3-MQ (3 micromol/kg, i. p.) significantly decreased the secretion of TNF-alpha, and at the highest dose (30 micromol/kg, i. p.) even decreased the secretions of IL-4, IL-5, and TNF-alpha. 3-O-Methylquercetin (1-10 microM) as well as Ro 20-1724 (3-30 microM), a selective PDE4 inhibitor, significantly attenuated OVA (100 microg/mL)-induced contractions. 3-O-Methylquercetin (30 microM) as well as milrinone (1-10 microM), a selective PDE3 inhibitor, significantly enhanced baseline contractions in isolated guinea pig left and right atria. However, neither 3-O-Methylquercetin nor milrinone significantly affected baseline beating rate in the right atria. 3-O-Methylquercetin (3-30 micromol/kg, i. p.) did not significantly affect systolic pressure in conscious mice. In conclusion, 3-O-Methylquercetin has both anti-inflammatory and bronchodilating effects, and has the potential for use in the treatment of asthma at a dose without affecting blood pressure.
    Citation [3]

    Planta Med. 2003 Apr;69(4):310-5.

    3-O-methylquercetin more selectively inhibits phosphodiesterase subtype 3.[Pubmed: 12709896]
    Rhamnus nakaharai Hayata (Rhamnaceae), has been used as a folk medicine in Taiwan for treating constipation, inflammation, tumors and asthma. 3-O-Methylquercetin (3-MQ), a main constituent of the plant, has been reported to inhibit total cAMP- and cGMP-phosphodiesterase (PDE) of guinea pig trachealis. Therefore we were interested in investigating the inhibitory effect of 3-O-Methylquercetin on various PDE isozymes from guinea pig lungs and hearts. Isolated guinea pig lungs and hearts were homogenized and centrifuged. The supernatant was chromatographed over a column of Q-sepharose, and eluted with various concentrations of NaCl. In the following order, PDE subtypes 1, 5, 2, 4 from lungs, and 3 from hearts were separated. The IC 50 values of 3-O-Methylquercetin on these isozymes were 31.9, 86.9, 18.6, 28.5 and 1.6 microM, respectively. 3-O-Methylquercetin (10-100 microM) non-competitively inhibited PDE2, but competitively inhibited PDE4. 3-O-Methylquercetin (1-10 microM) also competitively inhibited PDE3. However, 3-O-Methylquercetin (10-100 microM) did not competitively inhibit PDE1 and 5, although it had a tendency to competitively inhibit PDE1 at concentrations of 10 - 30 microM. The present results showed that K i value of 3-O-Methylquercetin was similar to that of milrinone in PDE3, and was not significantly different from that of Ro 20 - 1724 in PDE4, respectively. In conclusion, 3-O-Methylquercetin was revealed to be a selective and competitive PDE3/PDE4 inhibitor, although its inhibitory effect on PDE4 was not potent. Therefore, 3-O-Methylquercetin may have a potential in the treatment of asthma beside its antiviral activity.
    Citation [4]

    J Ethnopharmacol. 2006 Jan 16;103(2):281-7.

    Mechanisms of suppression of nitric oxide production by 3-O-methylquercetin in RAW 264.7 cells.[Pubmed: 16213685]
    Rhamnus nakaharai Hayata (Rhamnaceae) is used as a folk medicine in Taiwan for treating constipation, inflammation, tumors, and asthma. 3-O-Methylquercetin (3-MQ), a main constituent of the plant, has been reported to have potential for use in the treatment of asthma. The mechanisms of anti-inflammation of 3-O-Methylquercetin are still unclear. Nitric oxide (NO) production induced by lipopolysaccharide (LPS) through iNOS expression in RAW 264.7 cells, a mouse macrophage cell line, may reflect the degree of inflammation and may provide a measure for assessing the effect of drugs on the inflammatory process. Therefore, we were interested in investigating the mechanisms of suppression of NO production by 3-O-Methylquercetin in RAW 264.7 cells. 3-O-Methylquercetin (1-10 microM) concentration-dependently inhibited LPS (100 ng/mL)-induced NO production in RAW 264.7 cells. The IC(50) value was calculated to be 4.23 microM. 3-O-Methylquercetin(1-10 microM) significantly and concentration-dependently inhibited LPS (100 ng/mL)-induced iNOS protein and mRNA expressions in cells. The IC(50) values were calculated to be 4.36 and 6.53 microM, respectively. There was no significant difference among these three IC(50) values of 3-O-Methylquercetin. In conclusion, 3-O-Methylquercetinmay exert its anti-inflammatory effect through the inhibition of iNOS DNA transcription.