ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
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More articles cited ChemFaces products.
Int J Mol Sci. 2017 Dec 21;Polytechnic University of Catalonia2016Mol Immunol. 2016 Oct;78:121-132.J. Acta Agr. Scandinavica17 Apr 2017Acta ChromatographicaOct. 11, 2016
Int. J. of Food Properties08 Feb 2017;Front Pharmacol. 2017 Sep 29;Int J Mol Sci. 2014 May 13;15(5):8443-57.BMC Complement Altern Med.2017 Aug 3;BMC Complement Altern Med.2016 Jul 13
Sci Rep. 2017 Aug 15;Acta Physiologiae Plantarum.2014 10.Journal of Pharmaceutical Analysis2016 Dec.Tissue and Organ Culture (PCTOC)2016 Jun 28;
Our products had been exported to the following research institutions and universities, And still growing.
Hamdard University (India)Monash University Malaysia (Malaysia)Agricultural Research Organizati... (Israel)Chulalongkorn University (Thailand)
Max-Planck-Insitut (Germany)Universidade da Beira Interior (Germany)Molecular Biology Institute of B... (Spain)St. Jude Children Research Hospi... (USA)
Universidad de La Salle (Mexico)Yale University (USA)University of Lodz (Poland)
||Silydianin, an active constituent of Silybium marianum, has inhibitory effect on on the in vitro production and release of oxidative products. Silydianin has possible antiinflammatory activity, which regulates caspase-3 activation, affects cell membranes and acts as a free radical scavenger.|
|Phytother Res. 2006 Feb;20(2):115-9. |
|An in vitro study of the protective effect of the flavonoid silydianin against reactive oxygen species.[Pubmed: 16444663]|
|The inhibitory effect of Silydianin, an active constituent of Silybium marianum, on the in vitro production and release of oxidative products has been examined. Polymorphonuclear neutrophils (PMNs) play a primary role in the initiation and propagation of inflammatory responses. Their apoptosis is a major mechanism associated with the resolution of inflammatory reactions. Neutrophils were assessed for caspase-3 activity, the rst step in the execution phase of apoptosis.
METHODS AND RESULTS:
When cells were cultured with 100 microM Silydianin for 24 h, caspase-3 was activated. Induction of apoptosis by Silydianin was accompanied by a decrease in luminol-enhanced chemiluminescence as well as superoxide radical (O2*-) release in freshly isolated cells and lipid peroxidation in mouse spleen microsomes. No significant effect of Silydianin on PMN hydrogen peroxide production evaluated by a flow cytometric dichlorofluorescin oxidation assay was found.
Such results indicate a possible antiinflammatory activity for Silydianin, which regulates caspase-3 activation, affects cell membranes and acts as a free radical scavenger.
||The herbs of Silybum marianum (L.) Gaertn.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi: 10.1016/j.phymed.2017.12.030.PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Experientia. 1977 Dec 15;33(12):1568-9. |
|Peroxidase isoenzymes in cress seedlings (Lepidium sativum L.) and their inhibition by silybin, silydianin and silychristin[Pubmed: 590438]|
|Seedlings of Lepidium sativum L. contain 4 peroxidase isoenzymes. Their de-novo-synthesis is significantly depressed in the presence of 3.10(-3) moles/1 silybin, Silydianin and silychristin in the incubation medium respectively.|