3-Oxotirucalla-7,24-dien-21-oic acid | CAS:82464-35-5

3-Oxotirucalla-7,24-dien-21-oic acid

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Product Name	3-Oxotirucalla-7,24-dien-21-oic acid
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CAS No.:	82464-35-5
Catalog No.:	CFN97609
Molecular Formula:	C₃₀H₄₆O₃
Molecular Weight:	454.69 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The leaves of Rubus alceaefolius
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

3-Oxotirucalla-7,24-dien-21-oic acid shows potent cytotoxicity against MCF-7 cell line.

In vitro:

Revista Brasileira de Farmacognosia.2014 Oct;24(5):561–564.

Cytotoxic tirucallane triterpenes from the stem of Luvunga scandens.[Reference: WebLink]

METHODS AND RESULTS:
Two tirucallane triterpenes, namely flindissol (1) and 3-Oxotirucalla-7,24-dien-21-oic acid (2), were isolated from the dichloromethane extract of the stem of Luvunga scandens (Roxb.) Buch-Ham ex Wight & Arn, Rutaceae. This is the first report of their isolation from this plant. Their structures were constructed by high resolution mass and 2D NMR spectroscopic data. The cytotoxic potential of the two pure compounds 1 and 3-Oxotirucalla-7,24-dien-21-oic acid were determined by MTT assay against human breast adenocarcinoma cell line (MCF-7).
CONCLUSIONS:
Compounds 1 and 3-Oxotirucalla-7,24-dien-21-oic acid showed potent cytotoxicity against MCF-7 cell line with IC50 values of 13.8 μM and 27.5 μM, respectively. This result suggested their potential activity as antitumor agents.

3-Oxotirucalla-7,24-dien-21-oic acid Description

Source:	The leaves of Rubus alceaefolius
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Zhong Yao Cai. 2015 Jan;38(1):93-6.

Study on Chemical Constituents of Petroleum Ether Fraction from Rubus alceaefolius.[Pubmed: 26214876]

To investigate the chemical constituents of Rubus alceaefolius.
METHODS AND RESULTS:
Nine compounds were isolated and purified from the petroleum ether extract of 95% alcohol extract of Rubus alceaefolius by repeated column chromatography on silica, Sephadex LH-20 and structurally identified by spectral analysis. The compounds were identified as chrysophanol(1), physcion (2), β-sitosterol(3), 3-oxotirucalla-7, 24-dien-21-oic acid(4), myricadiol(5), 19-α-hydroxy-3-acetyl-ursolic acid(6), N-benzoylphenylalaninyl-N-benzoylphenylalaninate(7), aurantiamide acetate(8) and euscaphic acid(9).
CONCLUSIONS:
Compounds land 4~8 are isolated from this plant for the first time, and compounds 4 - 8 are found in plants of Rubus genus for the first time.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Antiviral Compound Library Triterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1993 mL	10.9965 mL	21.993 mL	43.986 mL	54.9825 mL
5 mM	0.4399 mL	2.1993 mL	4.3986 mL	8.7972 mL	10.9965 mL
10 mM	0.2199 mL	1.0997 mL	2.1993 mL	4.3986 mL	5.4983 mL
50 mM	0.044 mL	0.2199 mL	0.4399 mL	0.8797 mL	1.0997 mL
100 mM	0.022 mL	0.11 mL	0.2199 mL	0.4399 mL	0.5498 mL

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CFN92365	3beta-Hydroxylanosta-8,24-diene-21-al	96574-03-7	440.7	C₃₀H₄₈O₂
CFN92366	Trametenolic acid	24160-36-9	456.7	C₃₀H₄₈O₃
CFN90990	Tsugaric acid A	174391-64-1	498.8	C₃₂H₅₀O₄
CFN90991	Beta-Elemonic acid	28282-25-9	454.7	C₃₀H₄₆O₃
CFN90803	16 alpha-Hydroxytrametenolic acid	176390-68-4	472.7	C₃₀H₄₈O₄
CFN90804	3-O-Acetyl-16 alpha-hydroxytrametenolic acid	168293-13-8	514.8	C₃₂H₅₀O₅
CFN90577	Dehydrotrametenolic acid	29220-16-4	454.69	C₃₀H₄₆O₃
CFN90790	16alpha-Hydroxydehydrotrametenolic acid	176390-66-2	470.7	C₃₀H₄₆O₄
CFN90791	3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid	168293-14-9	512.7	C₃₂H₄₈O₅