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    3-Oxotirucalla-7,24-dien-21-oic acid
    3-Oxotirucalla-7,24-dien-21-oic acid
    Information
    CAS No. 82464-35-5 Price
    Catalog No.CFN97609Purity>=98%
    Molecular Weight454.69Type of CompoundTriterpenoids
    FormulaC30H46O3Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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  • Biological Activity
    Description: 3-Oxotirucalla-7,24-dien-21-oic acid shows potent cytotoxicity against MCF-7 cell line.
    In vitro:
    Revista Brasileira de Farmacognosia.2014 Oct;24(5):561–564.
    Cytotoxic tirucallane triterpenes from the stem of Luvunga scandens.[Reference: WebLink]

    METHODS AND RESULTS:
    Two tirucallane triterpenes, namely flindissol (1) and 3-Oxotirucalla-7,24-dien-21-oic acid (2), were isolated from the dichloromethane extract of the stem of Luvunga scandens (Roxb.) Buch-Ham ex Wight & Arn, Rutaceae. This is the first report of their isolation from this plant. Their structures were constructed by high resolution mass and 2D NMR spectroscopic data. The cytotoxic potential of the two pure compounds 1 and 3-Oxotirucalla-7,24-dien-21-oic acid were determined by MTT assay against human breast adenocarcinoma cell line (MCF-7).
    CONCLUSIONS:
    Compounds 1 and 3-Oxotirucalla-7,24-dien-21-oic acid showed potent cytotoxicity against MCF-7 cell line with IC50 values of 13.8 μM and 27.5 μM, respectively. This result suggested their potential activity as antitumor agents.
    3-Oxotirucalla-7,24-dien-21-oic acid Description
    Source: The leaves of Rubus alceaefolius
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1993 mL 10.9965 mL 21.993 mL 43.986 mL 54.9825 mL
    5 mM 0.4399 mL 2.1993 mL 4.3986 mL 8.7972 mL 10.9965 mL
    10 mM 0.2199 mL 1.0997 mL 2.1993 mL 4.3986 mL 5.4983 mL
    50 mM 0.044 mL 0.2199 mL 0.4399 mL 0.8797 mL 1.0997 mL
    100 mM 0.022 mL 0.11 mL 0.2199 mL 0.4399 mL 0.5498 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Zhong Yao Cai. 2015 Jan;38(1):93-6.
    Study on Chemical Constituents of Petroleum Ether Fraction from Rubus alceaefolius.[Pubmed: 26214876]
    To investigate the chemical constituents of Rubus alceaefolius.
    METHODS AND RESULTS:
    Nine compounds were isolated and purified from the petroleum ether extract of 95% alcohol extract of Rubus alceaefolius by repeated column chromatography on silica, Sephadex LH-20 and structurally identified by spectral analysis. The compounds were identified as chrysophanol(1), physcion (2), β-sitosterol(3), 3-oxotirucalla-7, 24-dien-21-oic acid(4), myricadiol(5), 19-α-hydroxy-3-acetyl-ursolic acid(6), N-benzoylphenylalaninyl-N-benzoylphenylalaninate(7), aurantiamide acetate(8) and euscaphic acid(9).
    CONCLUSIONS:
    Compounds land 4~8 are isolated from this plant for the first time, and compounds 4 - 8 are found in plants of Rubus genus for the first time.