4,4-di(4-hydroxy-3-methoxyphenly)-2,3-dimethylbutanol | CAS:913643-31-9 | Price: $368/5mg

4,4-di(4-hydroxy-3-methoxyphenly)-2,3-dimethylbutanol

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Description:

4,4-di(4-Hydroxy-3-methoxyphenly)-2,3-dimethylbutanol has antioxidant and potential cytotoxic abilities, it also shows inhibition against HIV-1 integrase.

Targets:

HIV

In vitro:

Biol Res. 2009;42(3):351-6.

Antioxidant isolated from Schisandra propinqua (Wall.) Baill.[Pubmed: 19915743 ]

Schisandra propinqua (Wall.) Baill.(Schisandraceae) is widely used as a Chinese folk medicine.
METHODS AND RESULTS:
In this study, activity-guided fractionation of the ethanol extract from the stem of Schisandra propinqua led to the isolation of four extracts. Subsequently, a neolignan 4,4-di(4-hydroxy-3-methoxyphenly)-2,3-dimethylbutanol was isolated from the EtOAc part of the stem of Schisandra propinqua, the free radical scavenging activities of which were researched in vitro. The present work demonstrated that extracts and pure compound possessed scavenging activities to DPPH, superoxide anions and hydroxy radical, and could depress lipid peroxidation reaction induced by oxygen radical produced by the Fe2+/cysteine system in vitro.
CONCLUSIONS:
This suggests that the traditional application of Schisandra propinqua in China may be related to its antioxidant activities, and the EtOAc part of the stems of Schisandra propinqua can be utilized as an effective source of antioxidants.

4,4-di(4-hydroxy-3-methoxyphenly)-2,3-dimethylbutanol Description

Source:	The herbs of Schisandra propinqua
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Kinase Assay:

Yao Xue Xue Bao. 2010 Feb;45(2):235-40.

Effective components against HIV-1 replicative enzymes isolated from plants.[Pubmed: 21351433]

Plant active components characterized of many different structures and activities on multiple targets, have made them to be the important sources of inhibitors on HIV-1.
METHODS AND RESULTS:
For finding leading compounds with new structure against HIV-1, three key HIV-1 replicative enzymes (reverse transcriptase, protease and integrase) were used as screening models. The in vitro activities of 45 plant derived components isolated from Schisandraceae, Rutaceae and Ranunculaceae were reported. Within twelve triterpene components isolated, eight compounds were found to inhibit HIV-1 protease, in these eight active compounds, kadsuranic acid A (7) and nigranoic acid (8), inhibited both HIV-1 protease and integrase; Among fifteen lignans, meso-dihydroguaiaretic acid (15) and kadsurarin (16) were active on HIV-1 reverse transcriptase, and 4,4-di(4-hydroxy-3-methoxyphenly)-2,3-dimethylbutanol(13) active on HIV-1 integrase.
CONCLUSIONS:
All of the six alkaloids, seven flavones, and five others compounds were not active or only with low activities against HIV-1 replicative enzymes. Further studies of the triterpene components showing strong inhibitory activities on HIV-1 were warranted.

Structure Identification:

Journal of Integrative Plant Biology, 2006, 48(12):1493-1497.

A Cytotoxic Neolignan from Schisandra propinqua (Wall.) Baill.[Reference: WebLink]

In the course of our study of bioactive natural products from Schisandra plants, we isolated a neolignan from an EtOAc extract of the stems of Schisandra propinqua (Wall.) Baill.
METHODS AND RESULTS:
The structure of the new compound was determined to be 4,4-di(4-hydroxy-3-methoxyphenly)-2,3-dimethylbutanol(compound 1) on the basis of 1H- and 13C-NMR spectra and 2D NMR methods. Eight known compounds, compounds 2-9, were also isolated and identified, of which compounds 3, 4, 6 and 9 were isolated for the first time from this plant. In addition, compounds 1-4 were evaluated for cytotoxicity by an 3-(4,5-dimethyl-2 thiazoyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay.
CONCLUSIONS:
Compound 1 showed significant potential cytotoxic ability in the bioassay.

CAS No.	913643-31-9	Price	$368 / 5mg
Catalog No.	CFN95200	Purity	>95%
Molecular Weight	346.4	Type of Compound	Phenols
Formula	C₂₀H₂₆O₅	Physical Description	Solid
Download	COA MSDS	Similar structural	Comparison

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Phenols Compound Library HIV Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8868 mL	14.4342 mL	28.8684 mL	57.7367 mL	72.1709 mL
5 mM	0.5774 mL	2.8868 mL	5.7737 mL	11.5473 mL	14.4342 mL
10 mM	0.2887 mL	1.4434 mL	2.8868 mL	5.7737 mL	7.2171 mL
50 mM	0.0577 mL	0.2887 mL	0.5774 mL	1.1547 mL	1.4434 mL
100 mM	0.0289 mL	0.1443 mL	0.2887 mL	0.5774 mL	0.7217 mL

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CFN90218	Corynoxine	6877-32-3	384.47	C₂₂H₂₈N₂O₄
CFN00129	Oteromycin	170591-45-4	487.68	C₃₂H₄₁NO₃
CFN98937	Asperglaucide	56121-42-7	444.5	C₂₇H₂₈N₂O₄