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    4'-Demethylpodophyllotoxin
    4'-Demethylpodophyllotoxin
    Information
    CAS No. 40505-27-9 Price $100 / 20mg
    Catalog No.CFN90483Purity>=98%
    Molecular Weight400.37Type of CompoundLignans
    FormulaC21H20O8Physical DescriptionCryst.
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: 4'-Demethylpodophyllotoxin exhibits the remarkable cytotoxic potential in diverse cancer cell lines.
    In vitro:
    Chem Biol Interact. 2014 Oct 18;224C:100-107.
    4'-Demethyl-deoxypodophyllotoxin glucoside isolated from Podophyllum hexandrum exhibits potential anticancer activities by altering Chk-2 signaling pathway in MCF-7 breast cancer cells.[Pubmed: 25446499]
    We investigated the root of Podophyllum hexandrum as a potential source of lead bioactive metabolites with anticancer activity.
    METHODS AND RESULTS:
    The present study led to the isolation of six known aryltetralin-type lignans designated as 4'-demethyl-deoxypodophyllotoxin (1), podophyllotoxin (2), 4'-Demethylpodophyllotoxin (3), podophyllotoxin-4-O-β-d-glucopyranoside (4), 4'-demethyl-deoxypodophyllotoxin-4-O-β-d-glucopyranoside (5), 4'-demethyl-podophyllotoxin-4-O-β-d-glucopyranoside (6), along with three known flavones Kaempferol (7), Quercetin (8), Astragalin (9) from the root of P. hexandrum. Compounds (1-9) exhibited the remarkable cytotoxic potential in diverse cancer cell lines.
    4'-Demethylpodophyllotoxin Description
    Source: The herbs of Dysosma pleiantha (Hance) Woodson.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4977 mL 12.4884 mL 24.9769 mL 49.9538 mL 62.4422 mL
    5 mM 0.4995 mL 2.4977 mL 4.9954 mL 9.9908 mL 12.4884 mL
    10 mM 0.2498 mL 1.2488 mL 2.4977 mL 4.9954 mL 6.2442 mL
    50 mM 0.05 mL 0.2498 mL 0.4995 mL 0.9991 mL 1.2488 mL
    100 mM 0.025 mL 0.1249 mL 0.2498 mL 0.4995 mL 0.6244 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.