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    5,7,4'-Trihydroxy-8-methylflavanone
    Information
    CAS No. 916917-28-7 Price
    Catalog No.CFN90711Purity>=98%
    Molecular Weight286.08Type of CompoundFlavonoids
    FormulaC16H14O5Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    5,7,4'-Trihydroxy-8-methylflavanone Description
    Source: The herbs of Scutellaria indica L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi: 10.1016/j.phymed.2017.12.030.

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4955 mL 17.4776 mL 34.9553 mL 69.9105 mL 87.3881 mL
    5 mM 0.6991 mL 3.4955 mL 6.9911 mL 13.9821 mL 17.4776 mL
    10 mM 0.3496 mL 1.7478 mL 3.4955 mL 6.9911 mL 8.7388 mL
    50 mM 0.0699 mL 0.3496 mL 0.6991 mL 1.3982 mL 1.7478 mL
    100 mM 0.035 mL 0.1748 mL 0.3496 mL 0.6991 mL 0.8739 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    5,7,4'-Trihydroxy-8-methylflavanone References Information
    Citation [1]

    Chinese Traditional & Herbal Drugs, 2010 , 41 (1) :19-23.

    Chemical constituents from Rhododendron spiciferum and their effects on immunocyte of mice.[Reference: WebLink]
    To study the chemical constituents from the leaves of Rhododendron spiciferum and their immunomodulatory activities. Methods The chemical constituents were isolated by various chromatography techniques and their structures were elucidated on the basis of spectroscopic data. The immunomodulatory activity of some compounds was examined by Balb/c mouse spleen lymphocyte proliferation through MTT. Results Twelve known flavonoids were isolated and identified as: quercetin-3-O-α-L-ara-binfuranside (1), quercetin-3-O-α-L-rhamnopyranoside (2), trans-taxifolin-3-O-α- arabinopyranoside (3), astilbin (4), 3-Orhamnoside engeletin (5), naringenin (6), (2S)-5,7,4'-Trihydroxy-8-methylflavanone (7), epicatechin- (2β→O→7,4β→8)-ent-epicatechin (8), proanthocyanidin A-l (9), bis-8, 8′-catechiny-lmethane (10), catechin (11), and epicatechin (12). The results showed that compounds 8, 9, and 11 alone or combined with ConA or LPS could significantly enhance the proliferation of spleen lymphocytes in a certain dose range. Conclusion This is the first report on the chemical constituents from R. spiciferum. Compounds 8,9, and 11 are found to be effect on increasing immunomodulatory activity.