6''-O-xylosyl-glycitin | CAS:231288-18-9

6''-O-xylosyl-glycitin

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

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More articles cited ChemFaces products.

Molecules. 2013, 18(11):14105-21

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Anal Chim Acta.2018, 1039:162-171

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Our products had been exported to the following research institutions and universities, And still growing.

The Australian National University (Australia)

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Michigan State University (USA)

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Description:

Reference standards.

In vitro:

Biol Pharm Bull. 2001 Oct;24(10):1117-21.

Tectorigenin, an isoflavone of Pueraria thunbergiana Benth., induces differentiation and apoptosis in human promyelocytic leukemia HL-60 cells.[Pubmed: 11642314]

Cytotoxic effects of six isoflavonoids, tectorigenin, glycitein, tectoridin, glycitin, 6''-O-xylosyltectoridin, and 6''-O-xylosyl-glycitin isolated from the flower of Pueraria thunbergiana Benth. together with genistein, a known differentiation and apoptosis inducer, were examined.
METHODS AND RESULTS:
Among these isoflavonoids, tectorigenin and genistein exhibited cytotoxicity against various human cancer cells; glycitein showed only mild cytotoxicity. These results suggest that the isoflavone structure and 5-hydroxyl group are crucial for the cytotoxic properties and that glycosides are inactive. Moreover, tectorigenin induced differentiation of human promyelocytic leukemia HL-60 cells to granulocytes and monocytes/macrophages, and caused apoptotic changes of DNA in the cells, as did genistein. Tectorigenin also inhibited autophosphorylation of epidermal growth factor (EGF) receptor by EGF and decreased the expression of Bcl-2 protein, with less activity than genistein.
CONCLUSIONS:
From these results, tectorigenin may be a possible therapeutic agent for leukemia.

6''-O-xylosyl-glycitin Description

Source:	The seeds of Glycine max
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

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Cell. 2018 Jan 11;172(1-2):249-261.e12.
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PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

CAS No.	231288-18-9	Price
Catalog No.	CFN80151	Purity	>=98%
Molecular Weight	578.16	Type of Compound	Flavonoids
Formula	C₂₇H₃₀O₁₄	Physical Description	Powder
Download	COA MSDS	Similar structural	Comparison (Web)

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.7296 mL	8.6481 mL	17.2963 mL	34.5925 mL	43.2406 mL
5 mM	0.3459 mL	1.7296 mL	3.4593 mL	6.9185 mL	8.6481 mL
10 mM	0.173 mL	0.8648 mL	1.7296 mL	3.4593 mL	4.3241 mL
50 mM	0.0346 mL	0.173 mL	0.3459 mL	0.6919 mL	0.8648 mL
100 mM	0.0173 mL	0.0865 mL	0.173 mL	0.3459 mL	0.4324 mL

CFN95091	Mirificin-4'-O-glucoside	168035-01-6	710.6	C₃₂H₃₈O₁₈
CFN90236	3'-Hydroxy Puerarin	117076-54-5	432.38	C₂₁H₂₀O₁₀
CFN90780	3'-Methoxypuerarin	117047-07-1	446.4	C₂₂H₂₂O₁₀
CFN99101	Daidzin	552-66-9	416.38	C₂₁H₂₀O₉
CFN70352	Daidzein 7-O-glucuronide	38482-80-3	430.4	C₂₁H₁₈O₁₀
CFN90755	Dihydrodaidzin	121927-96-6	418.4	C₂₁H₂₂O₉
CFN93005	4''-methyloxy-Daidzin	1195968-02-5	430.40	C₂₂H₂₂O₉
CFN91028	Daidzin 6''-O-malonate	124590-31-4	502.42	C₂₄H₂₂O₁₂
CFN92917	8-O-Methylretusin-7-O-beta-D-glucopyranoside	68862-13-5	460.43	C₂₃H₂₄O₁₀
CFN99136	Ononin	486-62-4	430.4	C₂₂H₂₂O₉