|Source:||The root of Scutellaria baicalensis Georgi|
|Biological Activity or Inhibitors:||1. Baicalin has diuretic activity.
2. Baicalin is a prolyl endopeptidase inhibitor, induces apoptosis in pancreatic cancer cells, and affects the GABA receptors.
3. Baicalin can control TH17 cell differentiation and may be a promising therapeutic agent for the treatment of TH17 cells-mediated inflammatory diseases.
|Solvent:||Pyridine, Methanol, Ethanol, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||2.2403 mL||11.2015 mL||22.4029 mL||44.8059 mL||56.0073 mL|
|5 mM||0.4481 mL||2.2403 mL||4.4806 mL||8.9612 mL||11.2015 mL|
|10 mM||0.224 mL||1.1201 mL||2.2403 mL||4.4806 mL||5.6007 mL|
|50 mM||0.0448 mL||0.224 mL||0.4481 mL||0.8961 mL||1.1201 mL|
|100 mM||0.0224 mL||0.112 mL||0.224 mL||0.4481 mL||0.5601 mL|
BMB Rep. 2015 Mar 5. pii: 3111.
|Baicalin, baicalein and wogonin inhibits high glucose-induced vascular inflammation in vitro and in vivo.[Pubmed: 25739393]|
|Data showed that HG induced markedly increased vascular permeability, monocyte adhesion, expressions of cell adhesion molecules (CAMs), formation of reactive oxygen species (ROS) and activation of nuclear factor (NF)-κB. Remarkably, all of the above mentioned vascular inflammatory effects of HG were attenuated by pretreatment with Baicalin, baicalein, and wogonin. Vascular inflammatory responses induced by HG are critical events underlying development of various diabetic complications, therefore, our results suggest that Baicalin, baicalein, and wogonin may have significant therapeutic benefits against diabetic complications and atherosclerosis.|
Inflammation. 2015 Jan 30.
|Baicalin Inhibits Lipopolysaccharide-Induced Inflammation Through Signaling NF-κB Pathway in HBE16 Airway Epithelial Cells.[Pubmed: 25630720]|
|These findings suggest that the anti-inflammatory properties of Baicalin may be resulted from the inhibition of IL-6, IL-8, and TNF-α expression via preventing signaling NF-κB pathway in HBE16 airway epithelial cells. In addition, this study provides evidence to understand the therapeutic effects of Baicalin on inflammatory diseases in clinical practice.|