6alpha-Hydroxypolyporenic acid C | CAS:24513-63-1

6alpha-Hydroxypolyporenic acid C

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Description:

6alpha-Hydroxypolyporenic acid C is a natural product from Wolfiporia cocos (Schw.) Ryv.

In vitro:

Zhongguo Zhong Yao Za Zhi. 2008 Jul;33(13):1596-601.

Absorption of triterpenoid compounds from Indian bread (Poria cocos) across human intestinal epithelial (Caco-2) cells in vitro.[Pubmed: 18837324]

To study the absorption of 3-epidehydrotumulosic acid (EDHTA), polyporenic acid C (PPAC) and 6alpha-Hydroxypolyporenic acid C (HPPA) isolated from the sclerotium of Poria cocos. In human intestinal epithelial.
METHODS AND RESULTS:
By using Caco-2 (the human colonic adenocarcinoma cell lines) cells monolayer as an intestinal epithelial cell model, the permeability of EDHTA, PPAC and 6alpha-Hydroxypolyporenic acid C were studied from apical side (AP side) to basolateral side (BL side) or from BL side to AP side.The P(app) values of EDHTA and PPAC were at a nearly same magnitude with those of propranolol, and 6alpha-Hydroxypolyporenic acid C lied between those of propranolol and atenolol. On the other hand, the efflux transport of EDHTA, PPAC and 6alpha-Hydroxypolyporenic acid C were higher 1.78, 1.91 and 2. 47 times more than its influx transport with 0.56, 0.52 and 0.41 rate of P(app A --> B)/P(app (B --> A).
CONCLUSIONS:
EDHTA, PPAC and 6alpha-Hydroxypolyporenic acid C can be absorbed across intestinal epithelial cells, among EDHTA and PPAC will be completely. 6alpha-Hydroxypolyporenic acid C will be moderately absorbed compounds. EDHTA, PPAC and 6alpha-Hydroxypolyporenic acid C may have been involved in efflux mechanism in Caco-2 cells monolayers model from the basolateral-to-apical direction.

6alpha-Hydroxypolyporenic acid C Description

Source:	The roots of Wolfiporia cocos (Schw.) Ryv.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

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CAS No.	24513-63-1	Price	$556 / 10mg
Catalog No.	CFN92741	Purity	>=98%
Molecular Weight	498.7	Type of Compound	Triterpenoids
Formula	C₃₁H₄₆O₅	Physical Description	Powder
Download	Manual COA MSDS	Similar structural	Comparison (Web)

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0052 mL	10.0261 mL	20.0521 mL	40.1043 mL	50.1303 mL
5 mM	0.401 mL	2.0052 mL	4.0104 mL	8.0209 mL	10.0261 mL
10 mM	0.2005 mL	1.0026 mL	2.0052 mL	4.0104 mL	5.013 mL
50 mM	0.0401 mL	0.2005 mL	0.401 mL	0.8021 mL	1.0026 mL
100 mM	0.0201 mL	0.1003 mL	0.2005 mL	0.401 mL	0.5013 mL

CFN92741	6alpha-Hydroxypolyporenic acid C	24513-63-1	498.7	C₃₁H₄₆O₅
CFN92838	Poricoic acid A(F)	137551-38-3	498.7	C₃₁H₄₆O₅
CFN96980	Poricoic acid AE	1159753-88-4	526.75	C₃₃H₅₀O₅
CFN96179	24(31)-Dehydrocarboxyacetylquercinic acid	127970-62-1	570.8	C₃₄H₅₀O₇
CFN90414	Eburicoic acid	560-66-7	470.73	C₃₁H₅₀O₃
CFN99590	Pachymic acid	29070-92-6	528.76	C₃₃H₅₂O₅
CFN92740	Dehydroeburicoic acid	6879-05-6	468.7	C₃₁H₄₈O₃
CFN92837	Dehydrotumulosic acid	6754-16-1	484.7	C₃₁H₄₈O₄
CFN92742	Dehydropachymic acid	77012-31-8	526.8	C₃₃H₅₀O₅
CFN92743	3-Epidehydrotumulosic acid	167775-54-4	484.7	C₃₁H₄₈O₄