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8alpha-Hydroxyhirsutinolide
8alpha-Hydroxyhirsutinolide
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 8alpha-Hydroxyhirsutinolide
Price:
CAS No.: 1394156-45-6
Catalog No.: CFN96809
Molecular Formula: C15H20O6
Molecular Weight: 296.31 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Powder
Source: The flowers of Vernonia cinerea.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Biological Activity
Description: 8alpha-Hydroxyhirsutinolide shows anti-inflammatory activity, it inhibits TNF-α-induced NF-κB activity with the IC(50) value of 1.9 uM.
Targets: NO | TNF-α | NF-kB
In vitro:
Bioorg Med Chem Lett. 2012 Sep 1;22(17):5559-62.
Anti-inflammatory sesquiterpene lactones from the flower of Vernonia cinerea.[Pubmed: 22850207 ]

METHODS AND RESULTS:
Bioassay-guided fractionation of the hexane extract from the flowers of Vernonia cinerea (Asteraceae) led to the isolation of a new sesquiterpene lactone, 8alpha-Hydroxyhirsutinolide (2), and a new naturally occurring derivative, 8α-hydroxyl-1-O-methylhirsutinolide (3), along with seven known compounds (1 and 4-9). The structures of the new compounds were determined by 1D and 2D NMR experiments and by comparison with the structure of compound 1, whose relative stereochemistry was determined by X-ray analysis. The isolated compounds were evaluated for their cancer chemopreventive potential based on their ability to inhibit nitric oxide (NO) production and tumor necrosis factor alpha (TNF-α)-induced NF-κB activity.
CONCLUSIONS:
Compounds 1, 2, 4, 5, and 9 inhibited TNF-α-induced NF-κB activity with IC(50) values of 3.1, 1.9, 0.6, 5.2, and 1.6 μM, respectively; compounds 4 and 6-9 exhibited significant NO inhibitory activity with IC(50) values of 2.0, 1.5, 1.2, 2.7, and 2.4 μM, respectively.
8alpha-Hydroxyhirsutinolide Description
Source: The flowers of Vernonia cinerea.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.3748 mL 16.8742 mL 33.7484 mL 67.4969 mL 84.3711 mL
5 mM 0.675 mL 3.3748 mL 6.7497 mL 13.4994 mL 16.8742 mL
10 mM 0.3375 mL 1.6874 mL 3.3748 mL 6.7497 mL 8.4371 mL
50 mM 0.0675 mL 0.3375 mL 0.675 mL 1.3499 mL 1.6874 mL
100 mM 0.0337 mL 0.1687 mL 0.3375 mL 0.675 mL 0.8437 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Aloenin A

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CAS No: 38412-46-3
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Delphinidin-3-sambubioside chloride

Catalog No: CFN92171
CAS No: 53158-73-9
Price: $318/5mg
Armepavine

Catalog No: CFN93348
CAS No: 524-20-9
Price: $388/10mg
Vincristine sulfate

Catalog No: CFN90400
CAS No: 2068-78-2
Price: $138/20mg
6-Hydroxyrubiadin

Catalog No: CFN97444
CAS No: 87686-86-0
Price: $218/5mg
3,9-Dihydroxypterocarpan

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5-O-Feruloylquinic acid

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