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    Acetoxyisovalerylalkannin
    Information
    CAS No. 69091-17-4 Price $418 / 20mg
    Catalog No.CFN92025Purity>=98%
    Molecular Weight430.5Type of CompoundQuinones
    FormulaC23H26O8Physical DescriptionRed powder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Acetoxyisovalerylalkannin may have anti-ageing activity, it can upregulate Collagen-I, elastin and involucrin syntheses in human dermal fibroblasts or keratinocytes.
    In vitro:
    Natural Product Research, 2015, Mar 26,30(5):574-577.
    Anti-skin ageing activity of napthoquinones from Arnebia nobilis Reichb.f.[Pubmed: 25810219]
    The present isolation and identification of napthoquinones from roots of Arnebia nobilis Reichb.f. can lead to the discovery of new anti-skin ageing ingredient in colour cosmetics.
    METHODS AND RESULTS:
    Four compounds have been isolated and purified by rigorous column chromatography. The compounds are identified as β, β-dimethylacryl alkannin (AN-I), Acetoxyisovalerylalkannin (AAN-II), acetyl alkannin (AN-III) and alkannin (AN-IV) by interpretation of spectroscopic data. This study is the first to report the isolation of Acetoxyisovaleryl alkannin (AAN-II) from A. nobilis. The IC50 values of the compounds, determined in human skin cells (human dermal fibroblasts and human keratinocytes) and mouse embryonic fibroblasts (NIH3T3) varied significantly among the four alkannins. Among the four compounds, β-acetoxyisovaleryl alkannin (AAN-II) significantly inhibited hydrogen peroxide (H2O2)-induced red blood corpuscle haemolysis and cellular senescence in human dermal fibroblasts. Collagen-I, elastin and involucrin syntheses in human dermal fibroblasts or keratinocytes were up regulated by AAN-II.
    CONCLUSIONS:
    These results support the potential utility of alkannins as novel anti-ageing ingredients.
    Acetoxyisovalerylalkannin Description
    Source: The roots of Lithosperraum erythrorhizon Sieb. et Zucc.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3229 mL 11.6144 mL 23.2288 mL 46.4576 mL 58.072 mL
    5 mM 0.4646 mL 2.3229 mL 4.6458 mL 9.2915 mL 11.6144 mL
    10 mM 0.2323 mL 1.1614 mL 2.3229 mL 4.6458 mL 5.8072 mL
    50 mM 0.0465 mL 0.2323 mL 0.4646 mL 0.9292 mL 1.1614 mL
    100 mM 0.0232 mL 0.1161 mL 0.2323 mL 0.4646 mL 0.5807 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Journal of Jilin University, 2010 , 48 (2) :319-322.
    Chemical Constituents from Root of Arnebia euchroma(Royle)Johnst[Reference: WebLink]
    All the compounds were separated from the petroleum ether extracts of Arnebia euchroma root by means of column chromatography and their structures were identified by the spectral analysis and chemical evidence.
    METHODS AND RESULTS:
    Seven compounds were separated and identified as deoxyshikonin (1),β,β-dimethylacryloylshikonin (2),acetyshikonin (3),shikonin (4),β-sitosterol (5),propionylshikonin (6),Acetoxyisovalerylalkannin (7).