Alatamine | CAS:41855-33-8 | Manufacturer ChemFaces

Alatamine

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Alatamine can markedly reduce acute myocardial ischemia (AMI)-induced cardiac injury and cardiac myocyte apoptosis, improve the expression and activity of sarcoplasmic/endoplasmic reticulum Ca(2+) ATPase (SERCA).

Targets:

Calcium Channel | ATPase | Bcl-2/Bax

In vivo:

Can. J.Physiol. Pharm., 2015, 94(4):433-40.

Cardiac-protective effects and the possible mechanisms of alatamine during acute myocardial ischemia.[Pubmed: 26863576 ]

Alatamine is a constituent in the extract of a traditional herbal medicine Ramulus euonymi widely used for cardiac protection.
METHODS AND RESULTS:
Mechanistically, it was also found that Alatamine improved the expression and activity of sarcoplasmic/endoplasmic reticulum Ca(2+) ATPase (SERCA), which were inhibited during AMI, promoting contractility and relaxation. Meanwhile, Alatamine decreased Bax and increased Bcl-2 expressions both in vivo and in vitro, therefore inhibiting cardiac myocyte apoptosis and preventing cardiac dysfunction caused by AMI at the cellular level.
CONCLUSIONS:
The present study revealed the beneficial role of Alatamine in cardiac protection and highlighted it as a potential therapeutic reagent for reduction of AMI-induced cardiac injury.

Alatamine Description

Source:	The herbs of Ramulus euonymi.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Alatamine
Price:
CAS No.:	41855-33-8
Catalog No.:	CFN92121
Molecular Formula:	C₄₁H₄₅NO₁₈
Molecular Weight:	839.8 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Powder
Source:	The herbs of Ramulus euonymi.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Cardioprotective Compound Library Anti-myocardial ischemia Compound Library Sesquiterpenoids Compound Library Calcium Channel Inhibitor Library Bcl-2/Bax Inhibitor Library ATPase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.1908 mL	5.9538 mL	11.9076 mL	23.8152 mL	29.769 mL
5 mM	0.2382 mL	1.1908 mL	2.3815 mL	4.763 mL	5.9538 mL
10 mM	0.1191 mL	0.5954 mL	1.1908 mL	2.3815 mL	2.9769 mL
50 mM	0.0238 mL	0.1191 mL	0.2382 mL	0.4763 mL	0.5954 mL
100 mM	0.0119 mL	0.0595 mL	0.1191 mL	0.2382 mL	0.2977 mL

CFN92120	Wilfornine A	345954-00-9	925.9	C₄₅H₅₁NO₂₀
CFN99207	Wilforine	11088-09-8	867.9	C₄₃H₄₉NO₁₈
CFN92121	Alatamine	41855-33-8	839.8	C₄₁H₄₅NO₁₈
CFN92103	Wilfordine	37239-51-3	883.9	C₄₃H₄₉NO₁₉
CFN92104	Peritassine A	150881-01-9	805.8	C₃₈H₄₇NO₁₈
CFN92118	Ebenifoline E-II	133740-16-6	929.9	C₄₈H₅₁NO₁₈
CFN92119	Mayteine	104736-05-2	867.9	C₄₃H₄₉NO₁₈