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    Aristolactam AII
    Information
    CAS No. 53948-07-5 Price
    Catalog No.CFN96013Purity>=98%
    Molecular Weight265.3Type of CompoundAlkaloids
    FormulaC16H11NO3Physical DescriptionYellow powder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Aristolactam AII has cytotoxic activity, it also shows platelet aggregation inhibitory activity.
    Targets: PAFR
    In vitro:
    Phytochemistry. 2013 Feb;86:121-6.
    Pyridocoumarin, aristolactam and aporphine alkaloids from the Australian rainforest plant Goniothalamus australis.[Pubmed: 23158725]

    METHODS AND RESULTS:
    Chemical investigation of the CH(2)Cl(2)/CH(3)OH extracts from aerial parts of the Australian plant Goniothalamus australis has resulted in the isolation of two pyridocoumarin alkaloids, goniothalines A (1) and B (2) as well as eight known natural products, Aristolactam AII (3), enterocarpam II (4), caldensine (5), sauristolactam (6), (-)-anonaine (7), asimilobine (8), altholactone (9) and ( )-goniofufurone (10). The chemical structures of all compounds were determined by extensive spectroscopic and spectrometric analysis. Methylation of 2 using TMS-diazomethane afforded 1, which unequivocally established that both 1 and 2 possessed a 10-methyl-2H-pyrano[2,3-f]quinolin-2-one skeleton. These pyridocoumarin alkaloids are putatively proposed to arise biosynthetically from an aporphinoid precursor. Compounds 1-10 were evaluated for in vitro antimalarial activity against a chloroquine-sensitive Plasmodium falciparum line (3D7).
    CONCLUSIONS:
    Sauristolactam (6) and (-)-anonaine (7) exhibited the most potent antiparasitic activity with IC(50) values of 9 and 7 μM, respectively.
    Aristolactam AII Description
    Source: The herbs of Aristolochia debilis Sieb. et Zucc
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.7693 mL 18.8466 mL 37.6932 mL 75.3864 mL 94.2329 mL
    5 mM 0.7539 mL 3.7693 mL 7.5386 mL 15.0773 mL 18.8466 mL
    10 mM 0.3769 mL 1.8847 mL 3.7693 mL 7.5386 mL 9.4233 mL
    50 mM 0.0754 mL 0.3769 mL 0.7539 mL 1.5077 mL 1.8847 mL
    100 mM 0.0377 mL 0.1885 mL 0.3769 mL 0.7539 mL 0.9423 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.