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    Bakkenolide IIIa
    Bakkenolide IIIa
    Information
    CAS No. 915289-60-0 Price
    Catalog No.CFN89054Purity>=98%
    Molecular Weight448.57Type of CompoundSesquiterpenoids
    FormulaC24H32O6SPhysical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison
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    Biological Activity
    Description: 1. Bakkenolide IIIa has neuroprotective effects, it protects against cerebral damage by inhibiting AKT and ERK1/2 activation and inactivated NF-κB signaling.
    2. Bakkenolide IIIa shows antioxidant activity.
    Targets: Akt | Bcl-2/Bax | p65 | NF-kB | IkB | ERK | IKK
    Bakkenolide IIIa Description
    Source: The rhizomes of Petasites formosanus.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi: 10.1016/j.phymed.2017.12.030.

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2293 mL 11.1465 mL 22.2931 mL 44.5861 mL 55.7327 mL
    5 mM 0.4459 mL 2.2293 mL 4.4586 mL 8.9172 mL 11.1465 mL
    10 mM 0.2229 mL 1.1147 mL 2.2293 mL 4.4586 mL 5.5733 mL
    50 mM 0.0446 mL 0.2229 mL 0.4459 mL 0.8917 mL 1.1147 mL
    100 mM 0.0223 mL 0.1115 mL 0.2229 mL 0.4459 mL 0.5573 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Bakkenolide IIIa References Information
    Citation [1]

    CNS Neurosci Ther. 2015 Dec;21(12):943-52.

    Bakkenolide-IIIa Protects Against Cerebral Damage Via Inhibiting NF-κB Activation.[Pubmed: 26511680 ]
    This study was designed to examine the neuroprotective effects of Bakkenolide IIIa, a major novel compound extracted from the rhizome of P. trichinous. METHODS: Transient focal cerebral damage model in rats and oxygen-glucose deprivation (OGD) in cultured hippocampal neurons were performed. The amount of apoptotic neurons was determined using TUNEL assay. The expressions of Bcl-2, Bax, Akt, ERK1/2, IKKβ, IκBα were measured using Western blot. The nuclear translocation and activation of NF-κB was measured using a fluorescence microscope and electrophoretic mobility shift assay (EMSA). RESULTS: Bakkenolide IIIa (4, 8, 16 mg/kg; i.g.) was administered immediately after reperfusion could reduce the brain infarct volume, and the neurological deficit, as well as a high dose of Bakkenolide IIIa, increases the 72 h survival rate in cerebrally damaged rats. In vitro data demonstrated that Bakkenolide IIIa could increase cell viability and decrease the amount of apoptotic cells in cultured primary hippocampal neurons exposed to OGD. Bakkenolide IIIa also dose-dependently increased the ratio of Bcl-2 to Bax. These results indicated that inhibition of apoptosis partly mediated the neuroprotection of Bakkenolide IIIa. Furthermore, Bakkenolide IIIa inhibited the phosphorylation of Akt, ERK1/2, IKKβ, IκBα, and p65 in cultured hippocampal neurons exposed to OGD. Bakkenolide IIIa not only inhibited the nuclear translocation of NF-κB in cultured neurons exposed to OGD, but also inhibited the activation of NF-κB in peri-infarct area in cerebrally damaged rats. CONCLUSION: Collectively, our findings indicated that Bakkenolide IIIa protects against cerebral damage by inhibiting AKT and ERK1/2 activation and inactivated NF-κB signaling.
    Citation [2]

    Planta Med. 2009 Feb;75(3):230-5.

    Bakkenolides from Petasites tricholobus and their neuroprotective effects related to antioxidant activities.[Pubmed: 19085813]
    Four novel bakkenolides - bakkenolide Ia ( 1), bakkenolide IIa ( 2), Bakkenolide IIIa ( 3) and bakkenolide IVa ( 4) - were isolated from the extract of the rhizome of Petasites tricholobus. The structures were characterized by using NMR ( (1)H, (13)C, (1)H- (1)H COSY, HMQC, HMBC, and NOESY) and mass spectrometry. The neuroprotective activity of the compounds 1 - 4 was assayed with primary cultured neurons exposed to oxygen-glucose deprivation and oxidative insults. Antioxidant activity of the bakkenolides was evaluated by cell-free bioassays. The IN VITRO assay results showed that all these compounds exhibited significant neuroprotective and antioxidant activities. To our knowledge, this is the first report on the neuroprotective and antioxidant activities of bakkenolides.