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    Betaine hydrochloride
    Information
    CAS No. 590-46-5 Price $40 / 20mg
    Catalog No.CFN99547Purity>=98%
    Molecular Weight153.60Type of CompoundAlkaloids
    FormulaC5H12ClNO2Physical DescriptionWhite cryst.
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Betaine hydrochloride is a natural compound found in many foods and also an active methyl-donor which can maintain normal DNA methylation patterns, which has anti-hypoxic, hepatoprotective, sedative, antipyretic and analgesic effects. Betaine hydrochloride can increase the secreting of thyroxine (T3) and insulin and regulate the metabolism of organism by the hormones, thus it prompts fish growth and also improves intestine figuration.
    Targets: Histone Methyltransferase
    In vivo:
    Journal of Fisheries of China, 2003, 27(6):564-9.
    Growth-promoting mechanism by betaine hydrochloride in Colossoma brachypomum.[Reference: WebLink]
    This research was conducted to approach growth-promoting mechanism by Betaine hydrochloride in Colossoma brachypomum fingerlings with average initial weight 83.14±15. 36g during October to December, 1997.
    METHODS AND RESULTS:
    The fish was fed for 60d under the conditions of circulation, filtration and controled temperature. The results of rearing indicated that Betaine hydrochloride obviously enhanced fish growth, decreased food conversion rate and improved feed efficiency; physiologically, Betaine hydrochloride increased the levels of T3 and insulin, increased the albumin content; Betaine hydrochloride decreased the urine nitrogen (UN) concentration significantly. The figure of tissue slices showed that Betaine hydrochloride improved villas and microvilli length, density and the distribution uniformity of duodenum. Betaine hydrochloride had no bad effects on supermicro-structure of live cell.
    CONCLUSIONS:
    The results of this research implicated that Betaine hydrochloride increases the secreting of thyroxine (T3) and insulin and regulates the metabolism of organism by the hormones. Thus it prompts fish growth. It also improved intestine figuration.
    Vet Med Nauki. 1976;13(6):66-71.
    [Effect of betaine hydrochloride on broiler chickens when used alone or in combination with vitamin B12].[Pubmed: 1014365 ]

    METHODS AND RESULTS:
    The studies were carried out with 2287 broilers aged from 3 to 56 days, divided when one-day-old into four equal groups. The first group were fed the common ration and served as controls. The remaining three groups were experimental, the broilers of the second group being offered the basic common ration enriched with 0.2 per cent betaine. The third group were also given the ordinary ration, however, they received in the drinking water some 10 mug vitamin BUI per one kilogram feed each. The fourth group received both betaine and vitamin B12 at the rates indicated.
    CONCLUSIONS:
    Results showed that Betaine hydrochloride offered either alone or in combination with vitamin B12 contributes to increasing the liveweight gain of broilers in the course of the starter period, but its use in doses of 0.2 per cent in the finishing period is not effective.
    Betaine hydrochloride Description
    Source: The roots of Beta vulgaris.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.5104 mL 32.5521 mL 65.1042 mL 130.2083 mL 162.7604 mL
    5 mM 1.3021 mL 6.5104 mL 13.0208 mL 26.0417 mL 32.5521 mL
    10 mM 0.651 mL 3.2552 mL 6.5104 mL 13.0208 mL 16.276 mL
    50 mM 0.1302 mL 0.651 mL 1.3021 mL 2.6042 mL 3.2552 mL
    100 mM 0.0651 mL 0.3255 mL 0.651 mL 1.3021 mL 1.6276 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Animal Research:
    Inpharma Weekly, 2001, 1311(1):10-10.
    Betaine hydrochloride shows promise for treatment of nonalcoholic steatohepatitis.[Reference: WebLink]
    Betaine hydrochloride shows promise for treatment of nonalcoholic steatohepatitisBetaine-hydrochloride, therapeutic useHepatitis, treatment...
    Acta Pharm. Sin., 1986, 21(1):61-4.
    The sedative, antipyretic and analgesic effects of betaine hydrochloride[Reference: WebLink]
    When Betaine hydrochloride was given orally 250~1000 mg/kg, the motor activity of mice was reduced 50~81%. The hypnotic effect of pentobarbital was markedly increased after oral administration of Betaine hydrochloride at the dosage of 500 mg/kg or 1000 mg/kg. Analgesic effect of betaine was demonstrated in mice by the hot plate method (55℃) and the acetic acid writhing test when given intraperitoneally at the dosage of 540 mg/kg or 900 mg/kg. The analgesic effect of betaine (500 mg/kg) was antagonized by prior administration of atropine (5 mg/kg). Betaine hydrochloride (500 mg/kg) given by gastric intubation was shown to have antipyretic effect in rabbits with ⅳ TAB vaccine fever, but not in normotheric rabbits.