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    Bruceine E
    Bruceine E
    Information
    CAS No. 21586-90-3 Price $318 / 5mg
    Catalog No.CFN89340Purity>=98%
    Molecular Weight412.43Type of CompoundDiterpenoids
    FormulaC20H28O9Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $524.6 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Kamphaengphet Rajabhat University (Thailand)
  • University of Beira Interior (Portugal)
  • Weizmann Institute of Science (Israel)
  • University of Lodz (Poland)
  • Universidade da Beira Interior (Germany)
  • Michigan State University (USA)
  • Siksha O Anusandhan University (India)
  • Institute of Bioorganic Chemist... (Poland)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Sanford Burnham Medical Researc... (USA)
  • Sri Ramachandra University (India)
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    Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
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  • Biological Activity
    Description: Bruceine E exhibits significant blood glucose concentration reduction activity, it might act as an insulin secretagogue.
    In vitro:
    Arch Pharm Res. 2011 Aug;34(8):1297-300.
    One new pregnane glycoside from the seeds of cultivated Brucea javanica.[Pubmed: 21910051]
    A new pregnane glycoside, named (20R)-O-(3)-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl-pregn-5-en-3β,20-diol (1), and seven known compounds, brusatol (2), bruceine B (3), bruceine D (4), yadanziolide A (5), Bruceine E (6), yadanzioside G (7), and yadanzioside B (8), were isolated from the cultivated dry seeds of Brucea javanica.
    METHODS AND RESULTS:
    The structure of 1 was elucidated on the basis of 1D- and 2D-NMR spectroscopic analyses. Their inhibitory effects on tumor cells were also tested. Compound 1 was slightly active against HL-60, SMMC-7721, A-549, and MCF-7 tumor cells. Compounds 2 and 3 demonstrated significant inhibitory activities against all tested cells.
    CONCLUSIONS:
    These results indicate that cultivated B. javanica could replace the wild plant as an antitumor plant resource.
    In vivo:
    J Ethnopharmacol. 2009 Jul 30;124(3):586-91.
    Hypoglycemic effect of quassinoids from Brucea javanica (L.) Merr (Simaroubaceae) seeds.[Pubmed: 19439174 ]
    The seeds of Brucea javanica (L.) Merr (Simaroubaceae) are recommended by traditional practitioners for the treatment of diabetes mellitus. To identify the compounds responsible for blood glucose lowering effect and evaluate the acute toxicity of the compounds.
    METHODS AND RESULTS:
    Extracts, fractions and subfractions were administered to normoglycemic mice and the blood glucose concentration was monitored for 8 h. Bioactive compounds isolated through column chromatography were administered to normoglycemic mice and streptozotocin (STZ) rats with monitoring of blood glucose concentration at 0-8h. The acute toxicity was evaluated in mice. Bioactivity-guided fractionation led to the isolation of Bruceine E (1) and bruceine D (2). Normoglycemic mice administered with 1 mg/kg of 1 and 2 exhibited significant blood glucose concentration reduction of 40.07+/-11.45% and 48.82+/-13.34%, respectively. STZ induced diabetic rats administered with 1 and 2 exhibited significant blood glucose concentration reduction of 73.57+/-13.64% and 87.99+/-2.91%, respectively.
    CONCLUSIONS:
    The reduction of blood glucose concentration by both bruceines was comparable to glibenclamide and they might act as an insulin secretagogue. The presence of a hydroxyl moiety at C(2) in 1 reduced the toxic effect by 9-fold compared to 2.
    Bruceine E Description
    Source: The seeds of Brucea javanica (L.) Merr.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4247 mL 12.1233 mL 24.2465 mL 48.4931 mL 60.6163 mL
    5 mM 0.4849 mL 2.4247 mL 4.8493 mL 9.6986 mL 12.1233 mL
    10 mM 0.2425 mL 1.2123 mL 2.4247 mL 4.8493 mL 6.0616 mL
    50 mM 0.0485 mL 0.2425 mL 0.4849 mL 0.9699 mL 1.2123 mL
    100 mM 0.0242 mL 0.1212 mL 0.2425 mL 0.4849 mL 0.6062 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.