ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $524.6 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Ind Crops Prod.2014, 62:173-178Acta Physiologiae Plantarum...2015...Int J Mol Med.2016, 37(2):501-8J Separation Science & Technology...2016...J Exp Bot.2016, 67(12):3777-88J Chromatogr A.2017, 1518:46-58Preprints2017, 2017120176Anal Chim Acta.2018, 1039:162-171
Pharmacognosy Magazine...2018...J Ethnopharmacol.2018, 210:88-94RSC Adv.2018, 32621-32636Biochem Biophys Res Commun....2018...Biochemical Systematics and Ecolo...2018...J Cancer.2019, 10(23):5843-5851Front Aging Neurosci.2019, 11:230Spectrochim Acta A2019, 210:372-380
Molecules.2019, 25(1):E103Phytother Res.2019, 33(5):1490-1500Kor. J. Herbol.2019, 34(2):59-66Korean Journal of Pharmacognosy....2019...Biochem Biophys Res Commun....2019...Toxicol In Vitro.2019, 59:161-178Industrial Crops and Products...2020...
Our products had been exported to the following research institutions and universities, And still growing.
Kamphaengphet Rajabhat University (Thailand)University of Beira Interior (Portugal)Weizmann Institute of Science (Israel)University of Lodz (Poland)
Universidade da Beira Interior (Germany)Michigan State University (USA)Siksha O Anusandhan University (India)Institute of Bioorganic Chemist... (Poland)
Instituto Politécnico de Bragan?a (Portugal)Sanford Burnham Medical Researc... (USA)Sri Ramachandra University (India)
Related Screening Libraries
|| Bruceine E exhibits significant blood glucose concentration reduction activity, it might act as an insulin secretagogue. |
|Arch Pharm Res. 2011 Aug;34(8):1297-300. |
|One new pregnane glycoside from the seeds of cultivated Brucea javanica.[Pubmed: 21910051]|
|A new pregnane glycoside, named (20R)-O-(3)-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl-pregn-5-en-3β,20-diol (1), and seven known compounds, brusatol (2), bruceine B (3), bruceine D (4), yadanziolide A (5), Bruceine E (6), yadanzioside G (7), and yadanzioside B (8), were isolated from the cultivated dry seeds of Brucea javanica.
METHODS AND RESULTS:
The structure of 1 was elucidated on the basis of 1D- and 2D-NMR spectroscopic analyses. Their inhibitory effects on tumor cells were also tested. Compound 1 was slightly active against HL-60, SMMC-7721, A-549, and MCF-7 tumor cells. Compounds 2 and 3 demonstrated significant inhibitory activities against all tested cells.
These results indicate that cultivated B. javanica could replace the wild plant as an antitumor plant resource.
|J Ethnopharmacol. 2009 Jul 30;124(3):586-91. |
|Hypoglycemic effect of quassinoids from Brucea javanica (L.) Merr (Simaroubaceae) seeds.[Pubmed: 19439174 ]|
|The seeds of Brucea javanica (L.) Merr (Simaroubaceae) are recommended by traditional practitioners for the treatment of diabetes mellitus. To identify the compounds responsible for blood glucose lowering effect and evaluate the acute toxicity of the compounds. |
METHODS AND RESULTS:
Extracts, fractions and subfractions were administered to normoglycemic mice and the blood glucose concentration was monitored for 8 h. Bioactive compounds isolated through column chromatography were administered to normoglycemic mice and streptozotocin (STZ) rats with monitoring of blood glucose concentration at 0-8h. The acute toxicity was evaluated in mice. Bioactivity-guided fractionation led to the isolation of Bruceine E (1) and bruceine D (2). Normoglycemic mice administered with 1 mg/kg of 1 and 2 exhibited significant blood glucose concentration reduction of 40.07+/-11.45% and 48.82+/-13.34%, respectively. STZ induced diabetic rats administered with 1 and 2 exhibited significant blood glucose concentration reduction of 73.57+/-13.64% and 87.99+/-2.91%, respectively.
The reduction of blood glucose concentration by both bruceines was comparable to glibenclamide and they might act as an insulin secretagogue. The presence of a hydroxyl moiety at C(2) in 1 reduced the toxic effect by 9-fold compared to 2.
Bruceine E Description
||The seeds of Brucea javanica (L.) Merr.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.