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Poricoic acid B
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $134.4 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Pharmacogn Mag.2015, 11(43):562-6Front Pharmacol.2016, 7:460Free Radic Biol Med.2017, 112:191-199Org Biomol Chem.2017, 15(31):6483-6492Int J Anal Chem.2017, 2017:1254721Plant Cell Tiss Org2017, 479-486Pharm Biol.2017, 55(1):360-366Sci Rep.2017, 7(1):3249
Nutrients.2018, 10(12)Microchemical Journal2018, 137:168-173Cell.2018, 172(1-2):249-261Evid Based Complement Alternat Me...2018...Molecules.2018, 23(12):E3103Molecules.2018, 23(9):E2121Front Pharmacol.2018, 9:756Cardiovasc Toxicol.2019, 19(4):297-305
J Ethnopharmacol.2019, 228:132-141Cell Physiol Biochem....2019...Journal of Chromatography A2020, 460942Appl. Sci.2020, 10(4),1304Pharmaceutics.2020, 12(9):845.Dicle Tip Dergisi2020, 47(2),423-430.Phytomedicine.2020, 79, 153351
Our products had been exported to the following research institutions and universities, And still growing.
Siksha O Anusandhan University (India)University of Oslo (Norway)Michigan State University (USA)University of Wuerzburg (Germany)
Sanford Burnham Prebys Medical ... (USA)National Hellenic Research Foun... (Greece)Kyoto University (Japan)Medical University of Gdansk (Poland)
Universidad de Buenos Aires (Argentina)Aveiro University (Portugal)The Ohio State University (USA)
Related Screening Libraries
|Size /Price /Stock
||10 mM * 100 uL in DMSO / Inquiry / In-stock |
10 mM * 1 mL in DMSO / Inquiry / In-stock
||Triterpenoids Compound Library
||Poricoic acid B shows inhibitory activity against TPA-induced ear inflammatory oedema, it also shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). |
|J Nat Prod. 2002 Apr;65(4):462-5. |
|Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos.[Pubmed: 11975480]|
|The structures of two novel 3,4-seco-lanostane-type triterpenes isolated from the sclerotium of Poria cocos were established to be 16alpha-hydroxy-3,4-seco-lanosta-4(28),8,24-triene-3,21-dioic acid (1; poricoic acid G) and 16alpha-hydroxy-3,4-seco-24-methyllanosta-4(28),8,24(24(1))-triene-3,21-dioic acid (2; poricoic acid H) on the basis of spectroscopic methods.
METHODS AND RESULTS:
These two, and eight other known compounds isolated from the sclerotium, Poricoic acid B (3), poricoic acid A (4), tumulosic acid (5), dehydrotumulosic acid (6), 3-epidehydrotumulosic acid (7), polyporenic acid C (8), 25-hydroxy-3-epidehydrotumulosic acid (9), and dehydroabietic acid methyl ester (10), showed potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Evaluation of the cytotoxicity of compounds 1 and 4 against human cancer cell lines revealed that 1 was significantly cytotoxic to leukemia HL-60 cells [GI(50) (concentration that yields 50% growth) value 39.3 nM], although it showed only moderate cytotoxicity to the other cells. Compound 4 exhibited moderate cytotoxicity to all of the cancer cell lines tested.
|Phytotherapy Research,1996,10(7):581-4. |
|Inhibitory Effect of Poria cocos on 12-O-Tetradecanoylphorbol-13Acetate‐Induced Ear Oedema and Tumour Promotion in Mouse Skin[Reference: WebLink]|
|The methanol extract from the sclerotium of Poria cocos was found to inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumour promotion in two-stage carcinogenesis in mouse skin.
METHODS AND RESULTS:
From the active fraction of the extract, eight lanostane-type triterpene acids and four 3,4-secolanostane-type triterpene acids were isolated. The isolated compounds showed inhibitory activity against TPA-induced ear inflammatory oedema. The 50% inhibitory dose of pachymic acid, 3-O-acetyl-16α-hydroxytrametenolic acid, dehydropachymic acid, dehydroeburiconic acid, 3β-hydroxylanosta-7,9(11),24-trien-21-oic acid, poricoic acid A and Poricoic acid B for TPA-induced inflammation was 17–44 μg/ear, at a grade corresponding to that of hydrocortisone.
Poricoic acid B Description
||The roots of Wolfiporia cocos (Schw.) Ryv.
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
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* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.