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    Buxbodine B
    Buxbodine B
    Information
    CAS No. 390362-51-3 Price
    Catalog No.CFN98626Purity>=98%
    Molecular Weight399.6 Type of CompoundAlkaloids
    FormulaC26H41NO2Physical DescriptionCryst.
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: 1. Buxbodine B has weak anti-AChE activity with IC50 values in the range of 10.8-98μM.
    Targets: AChR
    Buxbodine B Description
    Source: The herbs of Buxus bodinieri Levl.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi: 10.1016/j.phymed.2017.12.030.

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5025 mL 12.5125 mL 25.025 mL 50.0501 mL 62.5626 mL
    5 mM 0.5005 mL 2.5025 mL 5.005 mL 10.01 mL 12.5125 mL
    10 mM 0.2503 mL 1.2513 mL 2.5025 mL 5.005 mL 6.2563 mL
    50 mM 0.0501 mL 0.2503 mL 0.5005 mL 1.001 mL 1.2513 mL
    100 mM 0.025 mL 0.1251 mL 0.2503 mL 0.5005 mL 0.6256 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Buxbodine B References Information
    Citation [1]

    Steroids. 2015 Mar;95:73-9.

    Bioactive steroidal alkaloids from Buxus macowanii Oliv.[Pubmed: 25528196]
    Chemical investigation of the crude methanolic extract of Buxus macowanii resulted in the isolation of five new steroidal alkaloids, 31-hydroxybuxatrienone (1), macowanioxazine (2), 16α-hydroxymacowanitriene (3), macowanitriene (4), macowamine (5), along with five known steroidal bases, Nb-demethylpapillotrienine (6), moenjodaramine (7), irehine (8), Buxbodine B (9) and buxmicrophylline C (10). Structures of compounds 1-10 were elucidated with the aid of spectroscopic methods including 1D and 2D NMR techniques and mass spectrometry. Compounds 1, 3, and 4 belong to a rare class of Buxus alkaloids having Δ(1,2) 9(10→19) abeo triene system. All isolates were evaluated for in vitro acetylcholinesterase (AChE) inhibitory activity and found to exhibit moderate to weak anti-AChE activity with IC50 values in the range of 10.8-98μM. Compounds 1 and 6 were also moderately active in BACE1 inhibitory assay.
    Citation [2]

    Acta Botanica Yunnanica, 2001,23(3):357-62.

    Steroidal Alkaloids from Buxus bodinieri[Reference: WebLink]
    Five new steroidal alkaloids have been isolated from Buxus bodinieri Lévl.,a common ornamental in South-China. On the basis of IR, UV, MS, NMR spectral analyses and chemical evidence, the chemical structure of these new steroidal alkaloids were deduced as: buxbodine A (1)(20α- dimethylamino-9β,19-cyclo-4,4,14α-trimethy-5α-pregnane); Buxbodine B (2)(16β-hydroxy-20α-dimethylamino-9β,19-cyclo-4,4,14α-trimethy-5α-pregn-1(2)-en-3-one); buxbodine C (3)(3β-dimethylamino-9β,19-cyclo-4,4,14α-trimethy-5α-pregn-6(7), 17 (20)-dien-16-one), buxbodine D (4)(3β-dimethylamino-20α-acetoxylamino-9β,19-cyclo -4,4,14α-trimethy-5α-pregn-6(7)-ene) and buxbodine E (5)(3(-dimethylamino-20α-amino -9β,19-cyclo-4,4,14α-trimethy-5α-pregn-6(7)-ene), respectively.