Deoxyandrographolide | CAS:79233-15-1 | Manufacturer ChemFaces

Deoxyandrographolide

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Product Name	Deoxyandrographolide
Price:	$288 / 20mg
CAS No.:	79233-15-1
Catalog No.:	CFN90518
Molecular Formula:	C₂₀H₃₀O₄
Molecular Weight:	334.45 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The herbs of Andrographis paniculata (Burm. f.) Nees
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $103.4 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Deoxyandrographolide promotes glucose uptake through glucose transporter-4 translocation to plasma membrane in L6 myotubes and exerts antihyperglycemic effect in vivo.

Targets:

PI3K | Akt | AMPK | GLUT | LDL

In vivo:

Eur J Pharmacol. 2015 Dec 5;768:207-16.

Deoxyandrographolide promotes glucose uptake through glucose transporter-4 translocation to plasma membrane in L6 myotubes and exerts antihyperglycemic effect in vivo.[Pubmed: 26528798 ]

Skeletal muscle is the principal site for postprandial glucose utilization and augmenting the rate of glucose utilization in this tissue may help to control hyperglycemia associated with diabetes mellitus.
METHODS AND RESULTS:
Here, we explored the effect of Deoxyandrographolide (DeoAn) isolated from the Andrographis paniculata Nees on glucose utilization in skeletal muscle and investigated its antihyperglycemic effect in vivo in streptozotocin-induced diabetic rats and genetically diabetic db/db mice. In L6 myotubes, DeoAn dose-dependently stimulated glucose uptake by enhancing the translocation of glucose transporter 4 (GLUT4) to cell surface, without affecting the total cellular GLUT4 and GLUT1 content. These effects of DeoAn were additive to insulin. Further analysis revealed that DeoAn activated PI-3-K- and AMPK-dependent signaling pathways, account for the augmented glucose transport in L6 myotubes. Furthermore, DeoAn lowered postprandial blood glucose levels in streptozotocin-induced diabetic rats and also suppressed the rises in the fasting blood glucose, serum insulin, triglycerides and LDL-Cholesterol levels of db/db mice.
CONCLUSIONS:
These findings suggest the therapeutic efficacy of the DeoAn for type 2 diabetes mellitus and can be potential phytochemical for its management.

Deoxyandrographolide Description

Source:	The herbs of Andrographis paniculata (Burm. f.) Nees
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antihyperglycemic Compound Library Diterpenoids Compound Library PI3K Inhibitor Library LDL Inhibitor Library GLUT Inhibitor Library AMPK Inhibitor Library Akt Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.99 mL	14.9499 mL	29.8998 mL	59.7997 mL	74.7496 mL
5 mM	0.598 mL	2.99 mL	5.98 mL	11.9599 mL	14.9499 mL
10 mM	0.299 mL	1.495 mL	2.99 mL	5.98 mL	7.475 mL
50 mM	0.0598 mL	0.299 mL	0.598 mL	1.196 mL	1.495 mL
100 mM	0.0299 mL	0.1495 mL	0.299 mL	0.598 mL	0.7475 mL

CFN97600	Andropanolide	869807-57-8	350.45	C₂₀H₃₀O₅
CFN98923	Andrographolide	5508-58-7	350.5	C₂₀H₃₀O₅
CFN98666	14-Deoxy-11,12-didehydroandrographolide	42895-58-9	332.4	C₂₀H₂₈O₄
CFN99770	Dehydroandrographolide	134418-28-3	332.43	C₂₀H₂₈O₄
CFN92802	14-Deoxyandrographolide	4176-97-0	334.45	C₂₀H₃₀O₄
CFN90518	Deoxyandrographolide	79233-15-1	334.45	C₂₀H₃₀O₄
CFN97601	14-Deoxy-17-hydroxyandrographolide	869384-82-7	352.47	C₂₀H₃₂O₅
CFN97815	14-Deoxy-11-hydroxyandrographolide	160242-09-1	350.45	C₂₀H₃₀O₅
CFN97785	14-Deoxy-12-hydroxyandrographolide	219721-33-2	350.45	C₂₀H₃₀O₅
CFN96446	Vitexolide D	1788090-69-6	318.45	C₂₀H₃₀O₃