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    Calyxamine B
    Calyxamine B
    Information
    CAS No. 150710-72-8 Price
    Catalog No.CFN99627Purity>=98%
    Molecular Weight195.3 Type of CompoundAlkaloids
    FormulaC12H21NOPhysical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Anticholinesterase Compound Library
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  • Biological Activity
    Description: Calyxamine B has inhibitory activity on acetylcholinesterase, the effect is comparable to the natural inhibitors.
    In vitro:
    Tetrahedron Lett., 2013, 54 (50):6852-4.
    Two-step synthesis and biological evaluation of calyxamines A and B[Reference: WebLink]

    METHODS AND RESULTS:
    A two-step synthesis of naturally occurring alkaloids calyxamine A and Calyxamine B featuring a tandem Mannich–aldol condensation reaction under solvent free conditions, and their inhibitory activity against acetylcholinesterase (AChE) is reported.
    Calyxamine B Description
    Source: The herbs of Salsola tetrandra
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.1203 mL 25.6016 mL 51.2033 mL 102.4066 mL 128.0082 mL
    5 mM 1.0241 mL 5.1203 mL 10.2407 mL 20.4813 mL 25.6016 mL
    10 mM 0.512 mL 2.5602 mL 5.1203 mL 10.2407 mL 12.8008 mL
    50 mM 0.1024 mL 0.512 mL 1.0241 mL 2.0481 mL 2.5602 mL
    100 mM 0.0512 mL 0.256 mL 0.512 mL 1.0241 mL 1.2801 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J Nat Prod. 1997 Dec;60(12):1331-3.
    Calyxamines A and B, novel piperidine alkaloids from the Caribbean sea sponge Calyx podatypa.[Pubmed: 9428165]

    METHODS AND RESULTS:
    Calyxamine A (1) and Calyxamine B (2) are 2,2,4,6,6-pentasubstituted piperidine alkaloids possessing novel carbon skeletons isolated from the marine sponge Calyx podatypa collected in Puerto Rico.
    CONCLUSIONS:
    Their structures, after derivatization with trifluoroacetic acid, have been determined by a combination of X-ray and spectroscopic methods. A plausible biogenetic pathway to the calyxamines is suggested.