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    Catharanthine Tartrate
    Information
    CAS No. 2648-21-5 Price $100 / 20mg
    Catalog No.CFN90318Purity>=98%
    Molecular Weight486.40Type of CompoundAlkaloids
    FormulaC21H24N2O2.C4H6Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Catharanthine Tartrate is an anti-tumor drug. Catharanthine Tartrate binds with DNA in a mode of groove binding, Se(Ⅳ)can inhibit the binding of Catharanthine Tartrate and DNA.
    Targets: DNA/RNA Synthesis
    In vitro:
    CN20071097400
    Synthesizing method of vinorelbine tartrate[Reference: WebLink]

    METHODS AND RESULTS:
    The invention discloses a synthesis method of vinorelbine bitartrate which is characterized in that the method includes following steps: (1) having the Catharanthine Tartrate and vindoline as initial material, reacting with ferric trichloride and hydrochloric acid (2) reacting the above product with the sldium borohydride to get dehydrated vinblastine (3) ring-opening the dehydrated vinblastine by trifluoroacetic anhydride and rearranging to obtain the vinorelbine bitartrate.
    CONCLUSIONS:
    The method has a low production cost and a high yield and has a good application future.
    Catharanthine Tartrate Description
    Source: The herbs of Catharanthus roseus (L.) G.Don
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0559 mL 10.2796 mL 20.5592 mL 41.1184 mL 51.398 mL
    5 mM 0.4112 mL 2.0559 mL 4.1118 mL 8.2237 mL 10.2796 mL
    10 mM 0.2056 mL 1.028 mL 2.0559 mL 4.1118 mL 5.1398 mL
    50 mM 0.0411 mL 0.2056 mL 0.4112 mL 0.8224 mL 1.028 mL
    100 mM 0.0206 mL 0.1028 mL 0.2056 mL 0.4112 mL 0.514 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    《Journal of Huazhong Normal University(Natural Sciences)》 2011-04
    Study on the interaction between catharanthine tartrate and DNA by spectrometric method[Reference: WebLink]

    METHODS AND RESULTS:
    The interaction of Catharanthine Tartrate and DNA was studied using UV spectrometry,fluorescence spectrometry and fluorescent probe.The results showed that the fluorescence intensity of Catharanthine Tartrate was quenched in the presence of DNA,and this mechanism was judged as static quenching.The binding constant K at 25℃ and 40℃ were calculated as 5.38×104 and 5.85×102,and the binding sites number n as 1.405 and 0.8306.According to the binding constant K at 25℃ and 40℃,the thermodynamic parameters of the reaction of Catharanthine Tartrate and DNA were calculated as follows: ΔHm=-233.77 kJ·mol-1,ΔGm(298 K)=-27.0 kJ·mol-1,ΔSm(298 K)=-693.8 J·K-1·mol-1,and the main binding force between Catharanthine Tartrate and DNA is hydrogen bonding or van der Waals force according to thermodynamic parameters.
    CONCLUSIONS:
    The UV spectrometry test showed that as the DNA concentration increased,the blue shift of the absorbance peak occured and the absorbance decreased significantly,the results of fluorescence probe test further proved that Catharanthine Tartrate binds with DNA in a mode of groove binding.
    《Journal of Hainan Normal University(Natural Science)》 2014-03
    Study on the Effect of Se(Ⅳ) on the Interaction Between Catharanthine Tartrate and DNA[Reference: WebLink]

    METHODS AND RESULTS:
    The effect of Se(Ⅳ)on the interaction between Catharanthine Tartrate and DNA was studied by fluorescence spectrometry, UV spectroscopy and viscosity method. The results showed that the addition of Se(Ⅳ)changed the main binding force of Catharanthine Tartrate and DNA from hydrogen bond and van der Waals force into electrostatic force, and the binding mode from groove binding into electrostatic binding.
    CONCLUSIONS:
    The change of binding constant and the UV spectroscopy results showed that Se(Ⅳ)can inhibit the binding of Catharanthine Tartrate and DNA.