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    Celosin I
    Celosin I
    Information
    CAS No. 1807732-38-2 Price $288 / 5mg
    Catalog No.CFN91061Purity>=98%
    Molecular Weight1103.2Type of CompoundTriterpenoids
    FormulaC53H82O24Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $579.6 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
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    Description: Celosin H, celosin I, and celosin J could be used as chemical markers for the quality control of C. argentea seeds. Celosin I exhibited significant hepatoprotective effect on carbon tetrachloride-induced and N,N-dimethylformamide-induced hepatotoxicity in mice.
    In vivo:
    Nat Prod Res. 2013 Aug;27(15):1353-60.
    Novel triterpenoid saponins from the seeds of Celosia argentea L.[Pubmed: 23157342 ]

    METHODS AND RESULTS:
    Two new triterpenoid saponins Celosin I (1) and Celosin II (2) were isolated from the seeds of Celosia argentea L. (Amaranthaceae). The structures of the two new compounds were elucidated based on chemical analysis and spectral methods (IR, 1-D and 2-D NMR, ESI-MS, HR-ESI-MS).
    CONCLUSIONS:
    They exhibited significant hepatoprotective effect on carbon tetrachloride-induced and N,N-dimethylformamide-induced hepatotoxicity in mice.
    Celosin I Description
    Source: The herbs of Celosia argentea
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.9065 mL 4.5323 mL 9.0645 mL 18.1291 mL 22.6613 mL
    5 mM 0.1813 mL 0.9065 mL 1.8129 mL 3.6258 mL 4.5323 mL
    10 mM 0.0906 mL 0.4532 mL 0.9065 mL 1.8129 mL 2.2661 mL
    50 mM 0.0181 mL 0.0906 mL 0.1813 mL 0.3626 mL 0.4532 mL
    100 mM 0.0091 mL 0.0453 mL 0.0906 mL 0.1813 mL 0.2266 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J Asian Nat Prod Res. 2014;16(3):240-7.
    New oleanane-type triterpenoid saponins isolated from the seeds of Celosia argentea.[Pubmed: 24456247]

    METHODS AND RESULTS:
    Three new oleanane-type triterpenoid saponins named celosin H, Celosin I, and celosin J were isolated from the seeds of Celosia argentea L. Their structures were characterized as 3-O-β-D-xylopyranosyl-(1 → 3)-β-D-glucuronopyranosyl-polygalagenin 28-O-β-D-glucopyranosyl ester, 3-O-β-D-glucuronopyranosyl-medicagenic acid 28-O-β-D-xylcopyranosyl-(1 → 4)-α-L-rhamnopyranosyl-(1 → 2)-β-D-fucopyranosyl ester, and 3-O-β-D-glucuronopyranosyl-medicagenic acid 28-O-α-L-arabinopyranosyl-(1 → 3)-[β-D-xylcopyranosyl-(1 → 4)]-α-L-rhamnopyranosyl-(1 → 2)-β-D-fucopyranosyl ester by NMR, MS, and chemical evidences, respectively.
    CONCLUSIONS:
    In our opinion, celosin H, Celosin I, and celosin J could be used as chemical markers for the quality control of C. argentea seeds.