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Coccinic acid
Coccinic acid
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Product Name Coccinic acid
Price:
CAS No.: 107783-45-9
Catalog No.: CFN99083
Molecular Formula: C30H46O3
Molecular Weight: 454.7 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The roots of Kadsura coccinea
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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Biological Activity
Description: Coccinic acid shows inhibitory effects against colorectal carcinoma HCT-15 and oral epithelial cell line KB-3-1.Mixture of coccinic acid and anwuweizonic acid shows significant inhibitory activity against human decidual cells and rat luteal cells in vitro, suggests that it has antifertility activity.
Targets: Estrogen receptor | Progestogen receptor
In vitro:
Pharm Biol. 2013 Sep;51(9):1204-7.
Cytotoxic and potential anticancer constituents from the stems of Schisandra pubescens.[Pubmed: 23883077]

METHODS AND RESULTS:
Nine known compounds were obtained, including four lignans, epischisandrone (1), tigloylgomisin P (2), cagayanone (3) and (-)-gomisin L₂ (4), together with five triterpenoids, micranoic acid B (5), lancifodilactone H (6), Coccinic acid (7), schisanlactone B (8) and anwuweizonic acid (9).
CONCLUSIONS:
Compounds 2-6 and 8 showed moderate to marginal cytotoxicity, with GI₅₀ values of 11.83-35.65 μM.
Chinese Journal of Modern Applied Pharmacy, 2002, 19(2):103-5.
Antifertility Triterpenoid Acids from Kadsura angustifolia.[Reference: WebLink]
To isolate and characterize bioactive compounds from the stems of Kadsura angustifolia .
METHODS AND RESULTS:
The compounds were extracted with solvent,isolated by column chromatography and identified by the spectroscopic methods. eight compounds and a mixture of two triterpenoid acids were isolated and identified as epi anwuweizic acid (1),shikimic acid (2),(+) catechin (3),poriferast 5 en 3β,7α diol (4),β sitosterol (5),daucosterol (6),cerotic acid 1 monoglyceride (7) and behenic acid 1 monoglyceride (8),and mixiture of Coccinic acid (9) and anwuweizonic acid (10).
CONCLUSIONS:
Mixture of 9 and 10 showed significant inhibitory activity against human decidual cells and rat luteal cells in vitro . Compounds 2~4,7 and 8 were first reported in the family Schisandraceae,and compounds 1,5,6,9 and 10 were isolated from K.angustifolia for the first time.
Coccinic acid Description
Source: The roots of Kadsura coccinea
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

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doi: 10.1016/j.molcel.2017.10.022.
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doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
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IF=13.297(2019)

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1993 mL 10.9963 mL 21.9925 mL 43.985 mL 54.9813 mL
5 mM 0.4399 mL 2.1993 mL 4.3985 mL 8.797 mL 10.9963 mL
10 mM 0.2199 mL 1.0996 mL 2.1993 mL 4.3985 mL 5.4981 mL
50 mM 0.044 mL 0.2199 mL 0.4399 mL 0.8797 mL 1.0996 mL
100 mM 0.022 mL 0.11 mL 0.2199 mL 0.4399 mL 0.5498 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Planta Med. 1986 Dec;(6):492-3.
Triterpenoids from Roots and Stems of Kadsura coccinea.[Pubmed: 17345419]

METHODS AND RESULTS:
24-Methylenecycloartenone ( 1), kadsuric acid ( 2) and a new triterpenoid acid named Coccinic acid ( 3A) were isolated from the ether soluble fraction of the dried roots and stems of Kadsura coccinea.
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