ChemFaces is a professional high-purity natural products manufacturer.
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More articles cited ChemFaces products.
BMC Complement Altern Med.2014 Sep 23;14:352.Exp Parasitol.2017 Dec;Antiviral Res.2013 Jun;98(3):386-93.Kor. J. Pharmacogn.47(1):62-72(2016)Mol Cell2017 Nov 16;
Molecules.2013 Jun 24;18(7):7376-88.Mol Immunol. 2016 Oct;78:121-132.Br J Pharmacol.2016 Jan;173(2):396-410.Microchemical JournalMarch 2018;JPCMarch 16, 2017
Current Pharmaceutical AnalysisIssue 5, 2017Chem Pharm Bull (Tokyo).2017;65(9)Scientific Reports2015 August 26 Biochem Pharmacol. 2017 Apr 15;
Our products had been exported to the following research institutions and universities, And still growing.
University of Perugia (Italy)University of British Columbia (Canada)Universiti Putra Malaysia(UPM) (Malaysia)National Cancer Center Research ... (Japan)
Sri Ramachandra University (India)Wroclaw Medical University (Poland)Medizinische Universit?t Wien (Austria)Tokyo Woman's Christian University (Japan)
Universitas islam negeri Jakarta (Indonesia)Wageningen University (Netherlands)Worcester Polytechnic Institute (USA)
||Columbianetin-beta-D-glucopyranoside exhibits anti-inflammatory and analgesic properties, it also shows strong inhibiting activity against platelet aggregation.
||Immunology & Inflammation related|
|Yao Xue Xue Bao. 1989;24(7):546-51. |
|Studies of the active constituents of the Chinese drug [Pubmed: 2618698]|
METHODS AND RESULTS:
Eight coumarins isolated from the alcohol extract of the Chinese drug "Duhuo", the root of Angelica pubescents Maxim. f. biserrata Shan et Yuan (Umbelliferae) were elucidated to be columbianetin (I), columbianetin acetate (II), columbiadin (III), osthol (IV), isoimperatorin (V), bergapten (VI), xanthotoxin (VII), and Columbianetin beta-D-glucopyranoside (VIII), by chemical and spectral analysis, compound VIII was isolated from plant for the first time.
All these coumarins were tested on platelet aggregation induced by 2 microns ADP. I, II, III, IV and VIII showed strong inhibiting activity against platelet aggregation.
Columbianetin beta-D-glucopyranoside Description
||The roots of Angelica gigas
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|J Pharm Biomed Anal. 2018 May 10;153:221-231. |
|Simultaneous determination of columbianetin-β-d-glucopyranoside and columbianetin in a biological sample by high-performance liquid chromatography with fluorescence detection and identification of other columbianetin-β-d-glucopyranoside metabolites by u[Pubmed: 29506005]|
Columbianetin beta-D-glucopyranoside (CBG) and its metabolite columbianetin (CBN) are the bioactive constituents of Angelicae pubescentis radix (APR). They exhibit the anti-platelet aggregation, anti-inflammatory and analgesic properties. The absorption, distribution, metabolism and excretion (ADME) of CBG has not been reported to date.
METHODS AND RESULTS:
Both high-performance liquid chromatography with fluorescence detection and ultra high-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry methods were developed and validated for the study of ADME of CBG. It was found that CBG could be catabolized into its active metabolite CBN in vivo. The absolute bioavailability of columbianetin-β-d-glucopyranoside was 5.63 ± 4.42%. The other co-existing constituents from the APR ethanol extract could enhance the absorption of CBG. CBG and CBN were rapidly and broadly distributed in the stomach, ovary, kidney, liver, spleen, lung, muscles, heart and brain. Higher levels of accumulation of CBG and CBN were detected in the ovary and kidney tissues. Eight metabolites of CBG were tentatively identified in blood, urine, bile and faeces of rats after oral administration of pure CBG. It was also found that CBG and CBN were mainly excreted through the faecal route.
It can be concluded that the validated methods were successfully applied for absorption, distribution, metabolism and excretion study of CBG.