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    Natural Products
    Coclauril
    Coclauril
    Information
    CAS No. 127350-68-9 Price
    Catalog No.CFN99383Purity>=98%
    Molecular Weight151.2 Type of CompoundMiscellaneous
    FormulaC8H9NO2Physical DescriptionOil
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
    Citing Use of our Products
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    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • University of Padjajaran (Indonesia)
  • Utah State University (USA)
  • Universiti Sains Malaysia (Malaysia)
  • University of Maryland School o... (USA)
  • University of Dicle (Turkey)
  • University of Fribourg (Switzerland)
  • University of Wisconsin-Madison (USA)
  • Martin Luther University of Hal... (Germany)
  • University of Stirling (United Kingdom)
  • Calcutta University (India)
  • Julius Kühn-Institut (Germany)
  • More...
  • Package
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    Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
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  • Biological Activity
    Description: Coclauril shows anti-Hepatitis B virus (HBV) activities, with EC50 values of 7.6 ± 0.5 ug/mL.
    Targets: HBV
    In vitro:
    Molecules. 2015 Aug 12;20(8):14565-75.
    Four New Cyclohexylideneacetonitrile Derivatives from the Hypocotyl of Mangrove (Bruguiera gymnorrhiza).[Pubmed: 26274945 ]

    METHODS AND RESULTS:
    Four new cyclohexylideneacetonitrile derivatives 1-4, named menisdaurins B-E, as well as three known cyclohexylideneacetonitrile derivatives--menisdaurin (5), Coclauril (6), and menisdaurilide (7)--were isolated from the hypocotyl of a mangrove (Bruguiera gymnorrhiza). The structures of the isolates were elucidated on the basis of extensive spectroscopic analysis.
    CONCLUSIONS:
    Compounds 1-7 showed anti-Hepatitis B virus (HBV) activities, with EC50 values ranging from 5.1 ± 0.2 μg/mL to 87.7 ± 5.8 μg/mL.
    Coclauril Description
    Source: The herbs of Cocculus laurifolius
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

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    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.6138 mL 33.0688 mL 66.1376 mL 132.2751 mL 165.3439 mL
    5 mM 1.3228 mL 6.6138 mL 13.2275 mL 26.455 mL 33.0688 mL
    10 mM 0.6614 mL 3.3069 mL 6.6138 mL 13.2275 mL 16.5344 mL
    50 mM 0.1323 mL 0.6614 mL 1.3228 mL 2.6455 mL 3.3069 mL
    100 mM 0.0661 mL 0.3307 mL 0.6614 mL 1.3228 mL 1.6534 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.