ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $58.3 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
J Biol Chem.2014, 289(3):1723-31Tumour Biol.2015, 36(9):7027-34Ind Crops Prod.2015, 67:185-191Br J Pharmacol.2016, 173(2):396-410Molecules.2016, 21(10)Phytochem Anal.2016, 27(5):296-303Acta horticulturae2017, 1158:257-268Int J Anal Chem.2017, 2017:1254721
J Nat Med.2017, 71(2):457-462Oncotarget.2017, 8(64):108006-108019Oncology Letters2018, 4690-4696J of Health Science and Alternati...2019...Life Sci.2019, 216:259-270Molecules.2019, 24(10):E1926Molecules.2019, 24(16):E3003Food Chem.2019, 276:768-775
Planta Med.2019, 85(4):347-355LWT2020, 130:109535J Vet Sci.2020, 21(3):e39.J Med Food.2020, 23(6):633-640.Applied Biological Chemistry...2020...Pharmacol Rep.2020, 72(2):472-480.J Nat Med.2021, doi: 10.1007.
Our products had been exported to the following research institutions and universities, And still growing.
Kyushu University (Japan)University of Maryland (USA)University of East Anglia (United Kingdom)Center for protein Engineering ... (Belgium)
Hamdard University (India)Seoul National University of Sc... (Korea)Universidade Federal de Santa C... (Brazil)Universite de Lille1 (France)
University of Helsinki (Finland)Universidad de La Salle (Mexico)Colorado State University (USA)
Related Screening Libraries
|| Cosmosiin may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4 translocation.
|Evid Based Complement Alternat Med. 2011;2011:624375. |
|Insulin-Mimetic Action of Rhoifolin and Cosmosiin Isolated from Citrus grandis (L.) Osbeck Leaves: Enhanced Adiponectin Secretion and Insulin Receptor Phosphorylation in 3T3-L1 Cells.[Pubmed: 20008903]|
|Citrus grandis (L.) Osbeck (red wendun) leaves have been used in traditional Chinese medicine to treat several illnesses including diabetes. However, there is no scientific evidence supporting these actions and its active compounds. Two flavone glycosides, rhoifolin and Cosmosiin were isolated for the first time from red wendun leaves and, identified these leaves are rich source for rhoifolin (1.1%, w/w).|
METHODS AND RESULTS:
In differentiated 3T3-L1 adipocytes, rhoifolin and Cosmosiin showed dose-dependent response in concentration range of o.oo1-5 μM and 1-20 μM, respectively, in biological studies beneficial to diabetes. Particularly, rhoifolin and Cosmosiin at 0.5 and 20 μM, respectively showed nearly similar response to that 10 nM of insulin, on adiponectin secretion level. Furthermore, 5 μM of rhoifolin and 20 μM of Cosmosiin showed equal potential with 10 nM of insulin to increase the phosphorylation of insulin receptor-β, in addition to their positive effect on GLUT4 translocation.
These findings indicate that rhoifolin and Cosmosiin from red wendun leaves may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4 translocation.
||The flowers of Cosmos bipinnatus.
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.