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    Cuspidiol
    Cuspidiol
    Information
    CAS No. 51593-96-5 Price
    Catalog No.CFN96032Purity>=98%
    Molecular Weight236.3Type of CompoundPhenylpropanoids
    FormulaC14H20O3Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Cuspidiol shows cytotoxicity against Jurkat T cell clone E6.1 at 7.3 ug/mL.
    In vitro:
    Bull. Korean Chem. Soc., 2010, 31(4):1081-4.
    Cytotoxic Constituents from the Leaves of Zanthoxylum schinifoliu.[Reference: WebLink]

    METHODS AND RESULTS:
    The results showed that the methylene chloride fraction exhibited the strongest MTT cytotoxicity. Chromatographic separation of the methylene chloride and butanol fractions had yielded a quinolin (1), three phenylpropanoids (2, 3, 12), four coumarins (4 ~ 7), three triterpenoids (8 ~ 10), an alkaloid (11), an alcohol glucoside (13) and three monoterpene glucosides (14, 15, 16). One of these compounds were identified as new threo-6-amino-5-hydroxy-5-methyl- 1,3-oxazinan-4-one (11) together with fifteen known, 3-heptyl- 2-methylisoquinolin-1(2H)-one (1), integrifoliodiol (2), Cuspidiol (3), bergapten (4), aurapten (5), 8-hydroxy-7-methoxy- chromen-2-one (6), 6,7-dimethoxy-2H-naphthalen-1-one (7), lupeol (8), lupeone (9), β-sitosterol (10), syringin (12), 2-propyl alchol β-D-glucopyranoside (13), vomifoliol-9-O-β-D-glucopyranoside (14), betulalbuside A (15) and cnidioside C (16) on the basis of spectroscopic and chemical evidences.
    CONCLUSIONS:
    All of the compounds were isolated for the first time from this plant except 5 and 7. In the MTT cytotoxicity assay against Jurkat T cell clone E6.1, IC50 values of Cuspidiol (3) and auraptene (5) were obtained at 7.3 μg/mL and 16.5 μg/mL, respectively.
    Cuspidiol Description
    Source: The herbs of Zanthoxylum scandens
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.2319 mL 21.1595 mL 42.3191 mL 84.6382 mL 105.7977 mL
    5 mM 0.8464 mL 4.2319 mL 8.4638 mL 16.9276 mL 21.1595 mL
    10 mM 0.4232 mL 2.116 mL 4.2319 mL 8.4638 mL 10.5798 mL
    50 mM 0.0846 mL 0.4232 mL 0.8464 mL 1.6928 mL 2.116 mL
    100 mM 0.0423 mL 0.2116 mL 0.4232 mL 0.8464 mL 1.058 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.