Cycloartane-3,24,25-triol | CAS:57576-29-1

Cycloartane-3,24,25-triol

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Product Name	Cycloartane-3,24,25-triol
Price:
CAS No.:	57576-29-1
Catalog No.:	CFN98972
Molecular Formula:	C₃₀H₅₂O₃
Molecular Weight:	460.7 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The barks of Aphanamixis polystachya
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Cycloartane-3,24,25-triol has potential for development as an anti-cancer agent against prostate cancer. It reduces the viability of PC-3 and DU145 cell lines with IC50 values of 2.226 ± 0.28 μM and 1.67 ± 0.18 μM respectively.

Targets:

ATPase

In vitro:

Cancer Cell Int. 2012 Nov 14;12(1):46.

Cycloartane-3,24,25-triol inhibits MRCKα kinase and demonstrates promising anti prostate cancer activity in vitro.[Pubmed: 23151005]

Given the high occurrence of prostate cancer worldwide and one of the major sources of the discovery of new lead molecules being medicinal plants, this research undertook to investigate the possible anti-cancer activity of two natural cycloartanes; cycloartane-3,24,25-diol (extracted in our lab from Tillandsia recurvata) and Cycloartane-3,24,25-triol (purchased). The inhibition of MRCKα kinase has emerged as a potential solution to restoring the tight regulation of normal cellular growth, the loss of which leads to cancer cell formation.
METHODS AND RESULTS:
Kinase inhibition was investigated using competition binding (to the ATP sites) assays which have been previously established and authenticated and cell proliferation was measured using the WST-1 assay. Cycloartane-3,24,25-triol demonstrated strong selectivity towards the MRCKα kinase with a Kd50 of 0.26 μM from a total of 451 kinases investigated. Cycloartane-3,24,25-triol reduced the viability of PC-3 and DU145 cell lines with IC50 values of 2.226 ± 0.28 μM and 1.67 ± 0.18 μM respectively.
CONCLUSIONS:
These results will prove useful in drug discovery as Cycloartane-3,24,25-triol has shown potential for development as an anti-cancer agent against prostate cancer.

Cycloartane-3,24,25-triol Description

Source:	The barks of Aphanamixis polystachya
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Inhibitors Compound Library Triterpenoids Compound Library ATPase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1706 mL	10.853 mL	21.7061 mL	43.4122 mL	54.2652 mL
5 mM	0.4341 mL	2.1706 mL	4.3412 mL	8.6824 mL	10.853 mL
10 mM	0.2171 mL	1.0853 mL	2.1706 mL	4.3412 mL	5.4265 mL
50 mM	0.0434 mL	0.2171 mL	0.4341 mL	0.8682 mL	1.0853 mL
100 mM	0.0217 mL	0.1085 mL	0.2171 mL	0.4341 mL	0.5427 mL

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CFN96838	Gardenolic acid B	108864-53-5	486.69	C₃₀H₄₆O₅
CFN92972	Cimicifugoside H2	161097-77-4	634.8	C₃₅H₅₄O₁₀
CFN90863	Cimicidanol 3-O-alpha-L-arabinoside	161207-05-2	616.8	C₃₅H₅₂O₉
CFN92973	Cimicifugoside H1	163046-73-9	616.78	C₃₅H₅₂O₉
CFN92970	23-O-Acetylshengmanol 3-O-beta-D-xyloside	62498-88-8	662.85	C₃₇H₅₈O₁₀
CFN90498	Cycloart-23-ene-3,25-diol	14599-48-5	442.72	C₃₀H₅₀O₂
CFN97555	Cycloart-22-ene-3,25-diol	97456-49-0	442.7	C₃₀H₅₀O₂
CFN91991	Cycloart-24-ene-1alpha,2alpha,3beta-triol	942407-97-8	458.72	C₃₀H₅₀O₃
CFN91990	29-Norlanosta-8,24-diene-1alpha,2alpha,3beta-triol	119765-92-3	444.69	C₂₉H₄₈O₃