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  • Daidzin 6''-O-malonate
    • Daidzin 6''-O-malonate
    Daidzin 6''-O-malonate
    Information
    CAS No. 124590-31-4 Price $413 / 5mg
    Catalog No.CFN91028Purity>=98%
    Molecular Weight502.42Type of CompoundFlavonoids
    FormulaC24H22O12Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
    Citing Use of our Products
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    Size /Price /Stock 10 mM * 1 mL in DMSO / $475.0 / In-stock
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    • Biological Activity
    Description: Daidzin 6''-O-malonate may have anticancer activity.
    Targets: ROS | Nrf2 | HO-1 | SOD | Autophagy
    Daidzin 6''-O-malonate Description
    Source: The roots of Pueraria lobata
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9904 mL 9.9518 mL 19.9037 mL 39.8073 mL 49.7592 mL
    5 mM 0.3981 mL 1.9904 mL 3.9807 mL 7.9615 mL 9.9518 mL
    10 mM 0.199 mL 0.9952 mL 1.9904 mL 3.9807 mL 4.9759 mL
    50 mM 0.0398 mL 0.199 mL 0.3981 mL 0.7961 mL 0.9952 mL
    100 mM 0.0199 mL 0.0995 mL 0.199 mL 0.3981 mL 0.4976 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J Ind Microbiol Biotechnol. 2014 Nov;41(11):1647-58.
    Glycosylation and subsequent malonylation of isoflavonoids in E. coli: strain development, production and insights into future metabolic perspectives.[Pubmed: 25189810 ]

    METHODS AND RESULTS:
    Genistin and daidzein exhibit a protective effect on DNA damage and inhibit cell proliferation. Glycosylation and malonylation of the compounds increase water solubility and stability. Constructed pET15b-GmIF7GT and pET28a-GmIF7MAT were used for the transformation of Escherichia coli and bioconversion of genistein and daidzein. To increase the availability of malonyl-CoA, a critical precursor of GmIF7MAT, genes for the acyl-CoA carboxylase α and β subunits (nfa9890 and nfa9940), biotin ligase (nfa9950), and acetyl-CoA synthetase (nfa3550) from Nocardia farcinia were also introduced. Thus, the isoflavonoids were glycosylated at position 7 by 7-O-glycosyltranferase and were further malonylated at position 6(″) of glucose by malonyl-CoA: isoflavone 7-O-glucoside-6(″)-O-malonyltransferase both from Glycine max. Engineered E. coli produced 175.7 μM (75.90 mg/L) of genistin and 14.2 μM (7.37 mg/L) genistin 6''-O-malonate. Similar conditions produced 162.2 μM (67.65 mg/L) daidzin and 12.4 μM (6.23 mg/L) Daidzin 6''-O-malonate when 200 μM of each substrate was supplemented in the culture.
    CONCLUSIONS:
    Based on our findings, we speculate that isoflavonoids and their glycosides may prove useful as anticancer drugs with added advantage of increased solubility, stability and bioavailability.
    CFN95094Daidzein-4',7-diglucoside53681-67-7578.5C27H30O14
    CFN99141Calycosin-7-O-beta-D-glucoside20633-67-4446.40C22H22O10
    CFN894433'-Methoxydaidzin200127-80-6446.40C22H22O10
    CFN95142Daidzein-4'-glucoside58970-69-7416.4C21H20O9
    CFN90148Sophoricoside152-95-4432.38C21H20O10
    CFN95184New compound 3N/A594.5C27H30O15
    CFN90958Sophorabioside2945-88-2578.52C27H30O14
    CFN95159Genistein 7-O-beta-D-glucopyranoside-4'-O-[alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside]70404-42-1740.7C33H40O19
    CFN90250Genistin529-59-9432.38C21H20O10
    CFN70353Genistein 7-O-glucuronide38482-81-4446.4C21H18O11
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