ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $475.0 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Tumour Biol.2015, 36(9):7027-34J Chromatogr Sci.2015, 53(5):824-9Plant Cell,Tissue & Organ Culture...2016...J Ethnopharmacol.2016, 192:370-381Mol Pharm.2017, 14(9):3164-3177Phytochemistry.2017, 141:162-170Research on Crops.2017, 18(3):569J Ethnopharmacol.2017, 196:75-83
Srinagarind Medical Journal2017, 32(1)Sci Rep.2017, 7:46299Korean j.of Pharm.2017, 70-76Front Immunol.2017, 8:1542South African J of Plant&Soil...2018...Drug Invention Today...2019...Enzyme Microb Technol.2019, 122:64-73Molecules.2019, 24(10):E1926
Saudi Pharm J.2019, 27(1):145-153Chem Biol Interact.2019, 298:1-7Environ Toxicol.2019, 34(12):1354-1362Int J Cosmet Sci.2019, 41(1):12-20J Sep Sci.2019, 42(21):3352-3362J Agric Food Chem....2019...Food Research International2020, 108987
Our products had been exported to the following research institutions and universities, And still growing.
Auburn University (USA)National Research Council of Ca... (Canada)University of Virginia (USA)University of East Anglia (United Kingdom)
University of Wisconsin-Madison (USA)Colorado State University (USA)Charles Sturt University (Denmark)Institute of Tropical Disease U... (Indonesia)
Cancer Research Initatives Foun... (Malaysia)MTT Agrifood Research Finland (Finland)Instytut Nawozów Sztucznych w ... (Poland)
Related Screening Libraries
|| Daidzin 6''-O-malonate may have anticancer activity. |
||ROS | Nrf2 | HO-1 | SOD | Autophagy|
Daidzin 6''-O-malonate Description
||The roots of Pueraria lobata
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|J Ind Microbiol Biotechnol. 2014 Nov;41(11):1647-58. |
|Glycosylation and subsequent malonylation of isoflavonoids in E. coli: strain development, production and insights into future metabolic perspectives.[Pubmed: 25189810 ]|
METHODS AND RESULTS:
Genistin and daidzein exhibit a protective effect on DNA damage and inhibit cell proliferation. Glycosylation and malonylation of the compounds increase water solubility and stability. Constructed pET15b-GmIF7GT and pET28a-GmIF7MAT were used for the transformation of Escherichia coli and bioconversion of genistein and daidzein.
To increase the availability of malonyl-CoA, a critical precursor of GmIF7MAT, genes for the acyl-CoA carboxylase α and β subunits (nfa9890 and nfa9940), biotin ligase (nfa9950), and acetyl-CoA synthetase (nfa3550) from Nocardia farcinia were also introduced. Thus, the isoflavonoids were glycosylated at position 7 by 7-O-glycosyltranferase and were further malonylated at position 6(″) of glucose by malonyl-CoA: isoflavone 7-O-glucoside-6(″)-O-malonyltransferase both from Glycine max. Engineered E. coli produced 175.7 μM (75.90 mg/L) of genistin and 14.2 μM (7.37 mg/L) genistin 6''-O-malonate. Similar conditions produced 162.2 μM (67.65 mg/L) daidzin and 12.4 μM (6.23 mg/L) Daidzin 6''-O-malonate when 200 μM of each substrate was supplemented in the culture.
Based on our findings, we speculate that isoflavonoids and their glycosides may prove useful as anticancer drugs with added advantage of increased solubility, stability and bioavailability.