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    Dehydrotumulosic acid
    Information
    CAS No. 6754-16-1 Price $338 / 5mg
    Catalog No.CFN92837Purity>=98%
    Molecular Weight484.7Type of CompoundTriterpenoids
    FormulaC31H48O4Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Size /Price /Stock 10 mM * 1 mL in DMSO / $338 / In-stock
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    Description: Dehydrotumulosic acid shows anti-inflammatory activity.
    Targets: Immunology & Inflammation related
    Dehydrotumulosic acid Description
    Source: The roots of Wolfiporia cocos (Schw.) Ryv.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    IF=36.216(2019)

    PMID: 29328914

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    IF=22.415(2019)

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    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0631 mL 10.3157 mL 20.6313 mL 41.2626 mL 51.5783 mL
    5 mM 0.4126 mL 2.0631 mL 4.1263 mL 8.2525 mL 10.3157 mL
    10 mM 0.2063 mL 1.0316 mL 2.0631 mL 4.1263 mL 5.1578 mL
    50 mM 0.0413 mL 0.2063 mL 0.4126 mL 0.8253 mL 1.0316 mL
    100 mM 0.0206 mL 0.1032 mL 0.2063 mL 0.4126 mL 0.5158 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Anal Sci. 2002 May;18(5):529-31.
    The isolation, identification and determination of dehydrotumulosic acid in Poria cocos.[Pubmed: 12036119]
    Poria cocos (Fuling), a popular Chinese medicinal (CM) herb of fungal origin, has been included in many combinations with other CM herbs for its traditionally claimed activities of inducing diuresis, excreting dampness, invigorating the spleen and tranquilizing the mind and its modern pharmacological use of modulating the immune system of the body. Dehydrotumulosic acid, one of the effective constituents of Fuling, was isolated from the chloroform-soluble material of ethanol extract of the fungus.
    METHODS AND RESULTS:
    After further purification by a high-performance liquid chromatographic method on a C18 column, the purified constituent was identified using modern analytical techniques, such as UV, 13C-NMR and EI-MS. A reversed-phase high-performance liquid chromatographic method has been developed for the determination of Dehydrotumulosic acid in Poria cocos. The determination can be accomplished in less than 50 min using methanol-acetonitrile-2% glacial acetic acid as the mobile phase at a flow rate of 1.0 mL/min, with a UV detector setting at 242 nm and testosterone propionate used as an internal standard.
    CONCLUSIONS:
    This assay for Dehydrotumulosic acid is simple, rapid and with good reproducibility.
    J Chromatogr B Analyt Technol Biomed Life Sci. 2003 May 25;788(2):387-91.
    High-performance liquid chromatographic method for the determination and pharmacokinetic study of dehydrotumulosic acid in the plasma of rats having taken the traditional chinese medicinal preparation Ling-Gui-Zhu-Gan decoction.[Pubmed: 12705979]

    METHODS AND RESULTS:
    A high-performance liquid chromatographic method for the determination of Dehydrotumulosic acid in plasma of rats having been administrated orally with the traditional Chinese medicinal preparation Ling-Gui-Zhu-Gan decoction was developed. Plasma samples taken from rats were acidified with hydrochloric acid and extracted with ethyl acetate. Separation of the main effective constituent Dehydrotumulosic acid was accomplished on a C(18) stationary phase and a mobile phase of methanol-acetonitrile-2% glacial acetic acid (13:12:10, v/v), with a UV detector setting at 242 nm.
    CONCLUSIONS:
    After validation, the method was used for preliminary investigation of the pharmacokinetic profiles of Dehydrotumulosic acid administrated in Ling-Gui-Zhu-Gan decoction.