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    Deoxyartemisinin
    Information
    CAS No. 72826-63-2 Price
    Catalog No.CFN97212Purity>=98%
    Molecular Weight266.3 Type of CompoundSesquiterpenoids
    FormulaC15H22O4Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: 1. Deoxyartemisinin can inhibit microbial growth and reproduction,and is therefore likely to influence biochemical reactions in soils.
    Targets: Antifection
    Deoxyartemisinin Description
    Source: The herb of Artemisia annua L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi: 10.1016/j.phymed.2017.12.030.

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.7552 mL 18.7758 mL 37.5516 mL 75.1033 mL 93.8791 mL
    5 mM 0.751 mL 3.7552 mL 7.5103 mL 15.0207 mL 18.7758 mL
    10 mM 0.3755 mL 1.8776 mL 3.7552 mL 7.5103 mL 9.3879 mL
    50 mM 0.0751 mL 0.3755 mL 0.751 mL 1.5021 mL 1.8776 mL
    100 mM 0.0376 mL 0.1878 mL 0.3755 mL 0.751 mL 0.9388 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Deoxyartemisinin References Information
    Citation [1]

    Z Naturforsch C. 2010 Sep-Oct;65(9-10):607-12.

    Bioconversion of artemisinin to its nonperoxidic derivative deoxyartemisinin through suspension cultures of Withania somnifera Dunal.[Pubmed: 21138064]
    Biotransformation of artemisinin was investigated with two different cell lines of suspension cultures of Withania somnifera. Both cell lines exhibited potential to transform artemisinin into its nonperoxidic analogue, Deoxyartemisinin, by eliminating the peroxo bridge of artemisinin. The enzyme involved in the reaction is assumed to be artemisinin peroxidase, and its activity in extracts of W. somnifera leaves was detected. Thus, the non-native cell-free extract of W. somnifera and suspension culture-mediated bioconversion can be a promising tool for further manipulation of pharmaceutical compounds.
    Citation [2]

    Acta Prataculturae Sinica, 2015, 24(11):29-37.

    Artemisinin and flavonoids in wild Artemisia annuaand surrounding soil and the influence on soil microbes[Reference: WebLink]
    Artemisia annua releases various kinds of allelochemicals into soils via rain leaching,root exudation and dead tissue decomposition during the growing season,with resulting inhibition of the growth and development of adjacent plants and succeeding crops.The present experiments were thus conducted to detect artemisinin derivatives,flavonoids and effects on soil microbes in wild A.annuaand surrounding soil.The allelochemical concentrations ranked:bud break periodearly flowering periodfull bloom periodvegetative growth period(artemisinin in leaves and root zone soil)and stemleafrootflower(flavonoids in plants).In sampled soils,the mean concentration of Deoxyartemisinin was highest,followed by artemisic acid and artemisinin in soil and the sum of these artemisinin derivatives was 516.93μg/kg dry soil.Concentrations of all three compounds tested were highest in root surface soil and much higher in the root surface soil and rhizosphere soil than in non-rhizosphere soil.Soil flavonoid concentrations increased steadily during the growing season of A.annua and reached their highest levels at full-bloom stage(434.77μg/kg dry soil).Hence it is concluded that flavonoids are released into soils through root exudation.The numbers of bacteria and actinomycetes showed significant negative correlations with artemisinin concentration(r=-0.508*and-0.478*,n=24).There was also a negative correlation between deoxyartemsinin contents and actinomycete numbers(r=-0.528**,n=24).In summary,artemisinin and its derivatives released fromA.annuaappear to inhibit microbial growth and reproduction,and are therefore likely to influence biochemical reactions in soils.