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    Epimagnolin A
    Information
    CAS No. 41689-51-4 Price $268 / 10mg
    Catalog No.CFN90949Purity>=98%
    Molecular Weight416.46Type of CompoundLignans
    FormulaC23H28O7Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Epimagnolin A affects the transport activity of ABCB1(a major transmembrane efflux pump belonging to the ABC transporter superfamily), it also exhibits growth inhibitory activity against larvae of Drosophila melanogaster.
    Targets: ATPase | ABCB1
    In vitro:
    Phytochemistry, 1994, 35(00):611–613.
    An insect growth inhibitory lignan from flower buds of Magnolia fargesii.[Reference: WebLink]
    Bioassay-guided isolation afforded a new lignan, (+)-Epimagnolin A, from the flower buds of Magnolia fargesii. This lignan exhibited growth inhibitory activity against larvae of Drosophila melanogaster. The structure of a new lignan was determined on the basis of spectral methods.
    Epimagnolin A Description
    Source: The dried flower buds of Magnolia biondii Pamp.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

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    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi:10.1016/j.phymed.2017.12.030

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4012 mL 12.006 mL 24.0119 mL 48.0238 mL 60.0298 mL
    5 mM 0.4802 mL 2.4012 mL 4.8024 mL 9.6048 mL 12.006 mL
    10 mM 0.2401 mL 1.2006 mL 2.4012 mL 4.8024 mL 6.003 mL
    50 mM 0.048 mL 0.2401 mL 0.4802 mL 0.9605 mL 1.2006 mL
    100 mM 0.024 mL 0.1201 mL 0.2401 mL 0.4802 mL 0.6003 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    Planta Med 2016; 82(S 01): S1-S381.
    Preparation of epimagnolin A, a tetrahydrofurofuranoid lignan from Magnolia sp., and evaluation of anti-drug-resistance activity.[Reference: WebLink]
    Herbal products have been used to treat or prevent health problems for a long time. Although the biological effects of these products have been reported, their safety still remains to be elucidated. Therefore, studies are required to ensure their safe use. Among the herbal products listed in the Korean, Chinese, and Japanese Pharmacopoeias, Shin-i (Xin-yi/Flos magnoliae), dried flower buds of Magnolia fargesii or M. flos are one of the most commonly used traditional herbs for the treatment of allergic rhinitis, emphysema, headache, nasal congestion, and sinusitis. Tetrahydrofurofuranoid lignans, such as aschantin, dimethoxyaschantin, dimethylliroresinol, dimethylpinoresinol, Epimagnolin A, fargesin, and magnolin extracted from Shin-i have effects, such as anti-angiogenic, anti-allergic, anti-diabetic, anti-inflammatory, anti-microbial, and anti-rheumatoid arthritis. Among them, the pharmacokinetics of Epimagnolin A and magnolin have been reported, but not their molecular mechanisms.
    METHODS AND RESULTS:
    We examined the possibility of interaction between Epimagnolin A and human multidrug resistance protein ABCB1, a major transmembrane efflux pump belonging to the ABC transporter superfamily. In the calcein and ATPase assay [1], Epimagnolin A inhibited the extrusion of calcein by Flp-In-293/ABCB1 cells and stimulated the ATPase activity of ABCB1, respectively, in a concentration-dependent manner. It showed saturation kinetics between compound-stimulated ATPase activity and compound concentration, suggesting Michaelis-Menten kinetics similar to control drug, verapamil. The Km and Vmax values were calculated from Hanes-Woolf plots; epimagnolin, Km = 42.9 ± 7.53µM and Vmax = 156 ± 15.0µM and verapamil, Km = 12.3 ± 4.79µM and Vmax = 109 ± 3.18µM. In the MTT assay, the sensitivities of the Flp-In-293/ABCB1 cells to anti-cancer drugs were enhanced in the presence of 10µM Epimagnolin A.
    CONCLUSIONS:
    The present study results indicate that Epimagnolin A affects the transport activity of ABCB1.
    Structure Identification:
    J Sep Sci. 2007 Oct;30(15):2370-81.
    Isolation and purification of lignans from Magnolia biondii Pamp by isocratic reversed-phase two-dimensional liquid chromatography following microwave-assisted extraction.[Pubmed: 17628872]
    The dried flower buds of Magnolia biondii Pamp are one of the most widely used medicinal plants officially listed in the Chinese Pharmacopoeia.
    METHODS AND RESULTS:
    A 2-D column-switching system without sample loop trapping, where two columns were switched directly via a six-port two-position switching valve, was successfully applied for the first time to the isolation and purification of five lignans including pinoresinol dimethyl ether, magnolin, epi-magnolin A, fargesin, and demethoxyaschantin from M. biondii Pamp after microwave-assisted extraction. The introduction of the six-port switching valve instead of sample loop assured 100% recovery from the first dimension to the second, and the injection volumes of the second dimension could reach 12 mL.
    CONCLUSIONS:
    In this mode of operation, the solvent consumption of the 2-D approach was less than 30% that of conventional gradient methods with even larger sample size. The simultaneous operations of the two dimensions allowed the cycle time to be less than 16 min, compared to 90 min in the gradient elution single-dimension mode of operation. All of the five lignans were isolated at high purities of over 99% with approximately 95% recoveries.