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    Euphorbia factor L7a
    Euphorbia factor L7a
    Information
    CAS No. 93550-94-8 Price
    Catalog No.CFN92885Purity>=98%
    Molecular Weight548.7Type of CompoundDiterpenoids
    FormulaC33H40O7Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Description: Reference standards.
    Euphorbia factor L7a Description
    Source: The herbs of Euphorbia pekinensis Rupr.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8225 mL 9.1124 mL 18.2249 mL 36.4498 mL 45.5622 mL
    5 mM 0.3645 mL 1.8225 mL 3.645 mL 7.29 mL 9.1124 mL
    10 mM 0.1822 mL 0.9112 mL 1.8225 mL 3.645 mL 4.5562 mL
    50 mM 0.0364 mL 0.1822 mL 0.3645 mL 0.729 mL 0.9112 mL
    100 mM 0.0182 mL 0.0911 mL 0.1822 mL 0.3645 mL 0.4556 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Proceedings of the 19th National Conference on Organic Analysis and Bioanalysis of the Chinese Chemical Society 2017
    Analysis of Lathyrane Diterpenes as Modulators of P-Glycoprotein Dependent Multidrug Resistance.[Reference: WebLink]

    METHODS AND RESULTS:
    A series of lathyranediterpeneswere isolated or synthesized,and established on the basis of extensive spectroscopic methods,including two-dimensional NMR techniques.Stereo configuration and conformation of Euphorbia factor L1, Euphorbia factor L2, Euphorbia factor L7a, Euphorbia factor L7b, Euphorbia factor L8 and derivatives of L3 were analyzed by X-ray diffraction for the first time.The configuration of the unique isolathyrolditerpene Euphorbia factor L_(7b) was rectified from S* to R* at C-5.All compounds were examined as modulators of multidrug resistance on MCF-7/ADM cell lines in vitro.
    CONCLUSIONS:
    To obtain sufficient information on the structural characteristics of this class of compounds,the detailed fragmentation patterns of the lathyranediterpenes were studied with collision-induced dissociation(CID)–MS/MS using an ESI–quadrupole time-of-flight(QTOF)–MS/MS hybrid instrument in positive-ion mode.