|Source:||The fruiting bodys of Ganoderma lucidum|
|Biological Activity or Inhibitors:||1. Ganoderenic acid A show inhibitory activity on human aldose reductase in vitro.
2. Ganoderenic acid A has a potent hepatoprotective effect against CCl4-induced liver injury.
3. Ganoderenic acid A has cytotoxic activity, their inhibitory activities against human HeLa cervical cancer cell lines.
|Solvent:||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||1.9429 mL||9.7144 mL||19.4288 mL||38.8576 mL||48.572 mL|
|5 mM||0.3886 mL||1.9429 mL||3.8858 mL||7.7715 mL||9.7144 mL|
|10 mM||0.1943 mL||0.9714 mL||1.9429 mL||3.8858 mL||4.8572 mL|
|50 mM||0.0389 mL||0.1943 mL||0.3886 mL||0.7772 mL||0.9714 mL|
|100 mM||0.0194 mL||0.0971 mL||0.1943 mL||0.3886 mL||0.4857 mL|
Biol Pharm Bull. 1999 Feb;22(2):162-4.
|Beta-glucuronidase-inhibitory activity and hepatoprotective effect of Ganoderma lucidum.[Pubmed: 10077435]|
|To prove the relationship between the fluctuation in serum beta-glucuronidase level and hepatotoxicity, an inhibitor of beta-glucuronidase from G. lucidum was isolated and its hepatoprotective activity was investigated. The ether fraction of G. lucidum, which had potent beta-glucuronidase-inhibitory activity, protected against CCl4-induced liver injury. From this ether fraction, Ganoderenic acid A, was isolated as the potent inhibitor of beta-glucuronidase. It had a potent hepatoprotective effect against CCl4-induced liver injury. These results suggest that the beta-glucuronidase seems to be closely related to liver injury, which could be prevented by beta-glucuronidase inhibitors.|
Planta Med. 2010 Oct;76(15):1691-3.
|Inhibition of aldose reductase in vitro by constituents of Ganoderma lucidum.[Pubmed: 20379959]|
|CHCl(3) extract of the fruiting body of Ganoderma lucidum was found to show inhibitory activity on human aldose reductase in vitro. From the acidic fraction, potent human aldose reductase inhibitors, ganoderic acid C2 (1) and Ganoderenic acid A (2), were isolated together with three related compounds. It was found that the free carboxyl group of ganoderic acid C2 and Ganoderenic acid A is essential in eliciting the inhibitory activity considering the much lower activity of their methyl esters.|