Gardenoside | CAS:24512-62-7 | Manufacturer ChemFaces

Gardenoside

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Description:

Gardenoside has hepatoprotective, pain‑relieving, and anti-mastitis effects. it may be a potential therapeutic herb against NASH by suppressed supernatant inflammatory cytokine production and intracellular NFkB activity. Gardenoside may be considered potential drug candidates that target P2X3 and P2X7 purine receptors.

Targets:

In vivo:

Chinese Journal of Information on Tcm, 2004, 11(6):500-502.

Effect of Concha Margatitifera Usta, Cholic Acid, Gardenoside, Baicalin on MCP-1 in the Ischemic Cerebral Tissue of Rats after Middle Cerebral Artery Occlusion.[Reference: WebLink]

To study the effect of Concha Margatitifera Usta, Cholic Acid, Gardenoside, Baicalin on the protein levels of monocyte chemoattractant protein (MCP-1) in the ischemic cerebral tissue of rats after middle cerebral artery occlusion in rats.
METHODS AND RESULTS:
The 110 male SD rats were randomly assigned to the normal group, middle cerebral artery occlusion for 12 hours group and Concha Margatitifera Usta, Cholic Acid, Gardenoside, Baicalin cure middle cerebral artery occlusion for 12 hours group, middle cerebral artery occlusion for 24 hours group and Concha Margatitifera Usta, Cholic Acid, Gardenoside, Baicalin cure middle cerebral artery occlusion for 24 hours group. The protein levels of MCP-1 were measured by enzyme linked immunosorbent assay (ELISA). The protein level of MCP-1 of the ischemic cerebral tissue of rats in the middle cerebral artery occlusion for 12 hours group was markedly increased than the normal group (P0.05). The protein level of MCP-1 of the ischemic cerebral tissue of rats in Concha Margatitifera Usta and Gardenoside cure middle cerebral artery occlusion for 12 hours group were significantly lower than it in the middle cerebral artery occlusion for 12 hours group (P0.01). There was no significant change on the protein level of MCP-1 in the ischemic cerebral tissue of rats between Cholic Acid, Baicalin cure middle cerebral artery occlusion for 12 hours group and the middle cerebral artery occlusion for 12 hours group. The protein level of MCP-1 of the ischemic cerebral tissue of rats in the middle cerebral artery occlusion for 24 hours group was markedly increased than the normal group (P0.05). The protein level of MCP-1 of the ischemic cerebral tissue of rats in the Concha Margatitifera Usta, Cholic Acid, Gardenoside ,Baicalin cure middle cerebral artery occlusion for 24 hours group were significantly lower than it in the middle cerebral artery occlusion for 24 hours group (P0.05 or P0.01).
CONCLUSIONS:
Reducing the level of MCP-1 of the ischemic cerebral tissue of rats after ischemia may be one of the most important ways for the neuroprotective effects the middle cerebral artery occlusion group.

Chinese Veterinary Science, 2013, 43(8):876-880.

Inhibited effects of gardenoside on the LPS-induced mice mastitis[Reference: WebLink]

METHODS AND RESULTS:
To investigate the protective effects of Gardenoside on the mice against mastitis,48 male and female mice were paired and randomly divided into 6 groups.Mouse mastitis models were established by pouring LPS into mammary gland after farrowing.Female mice with mastitis were treated with different concentrations of Gardenoside(25,50 and 100 mg/kg) and dexamethasone,respectively. Mammary glands of the mice were collected at 24 h after the treatment to study the effects of Gardenoside on the histopathology and the expression of myeloperoxidase(MPO),TNF-α,IL-6 and IL-1β. In result,the expression levels of TNF-α,IL-6 and IL-1β were significantly higher in the LPS group than the normal group,indicating the model of mastitis was established successfully in this study.Mammary gland pathological damages were significantly inhibited by Gardenoside treatment compared with the LPS group(P0.01).MPO expression levels were decreased with the treatment of low,medium and high doses of Gardenoside,and the expression levels of TNF-α,IL-6 and IL-1β were significantly lower in the Gardenoside group than the dexamethasone group.
CONCLUSIONS:
These results indicated that Gardenoside has inhibitory effect on mice mastitis,and the inhibitory effect exhibits a dose-dependent manner.

Gardenoside Description

Source:	The fruits of Gardenia jasminoides Ellis
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

International Journal of Molecular Sciences, 2015, 16(11):27749-27756.

Inhibitory Effect of Gardenoside on Free Fatty Acid-Induced Steatosis in HepG2 Hepatocytes[Pubmed: 26610473]

Gardenoside is one of the most important effective extractions of a herb for its hepatoprotective properties. The aim of this study was to address the mechanism of Gardenoside on HepG2 cellular steatosis induced by free fatty acids (FFAs). The model of HepG2 steatosis was duplicated by oleic and palmitic acid at the proportion of 2:1 (FFAs mixture) for 24 h, then lipid toxicity was induced.
METHODS AND RESULTS:
3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) were used to detect cell viability and Oil Red O staining method was used to judge the lipid accumulation respectively. Inflammatory cytokines TNF-α, IL-1β, IL-6 and intracellular NFκB were measured after 24 h. The steatosis was significantly decreased after Gardenoside treatment without cytotoxicity. TNF-α, IL-1β, IL-6 were modulated to HepG2 cells by treatment of Gardenoside. In the meantime, the activation of NFκB was inhibited by Gardenoside.
CONCLUSIONS:
Gardenoside has a protective effect on FFA-induced cellular steatosis in HepG2 cells which indicates that Gardenoside might be a potential therapeutic herb against NASH by suppressed supernatant inflammatory cytokine production and intracellular NFkB activity.

Animal Research:

Molecular Medicine Reports, 2018, 17(6):7980-7986.

Gardenoside combined with ozone inhibits the expression of P2X3 and P2X7 purine receptors in rats with sciatic nerve injury.[Pubmed: 29620177]

Neuropathic pain is a severe health problem for which there is a lack of effective therapy. Ozone and Gardenia fruits have been used separately in pain relief for many years; however, their underlying mechanisms remain unclear. To investigate the pain‑relieving effects of combined ozone and Gardenia, a chronic constriction sciatic nerve injury (CCI) rat model was constructed and treated with ozone and Gardenoside (Ozo&Gar), which is a compound found in Gardenia fruits.
METHODS AND RESULTS:
A total of 70 rats were randomly divided into five groups: Control (Ctrl), Ctrl + Ozo&Gar, Sham, CCI, and CCI + Ozo&Gar. The rats in the Ctrl + Ozo&Gar and CCI + Ozo&Gar groups were administered an intravenous injection of 30 μg/ml ozone and 300 μmol/l Gardenoside. The rats in the Ctrl, Sham and CCI groups were administered the same volume of saline. Pain behavior, mechanical hyperalgesia, thermal hyperalgesia, and the protein expression levels of P2X3 and P2X7 purine receptors in L4‑L5 dorsal root ganglion (DRG) were determined 15 days post‑surgery. The results demonstrated that treatment with a combination of ozone and Gardenoside increased mechanical withdrawal threshold and thermal withdrawal latency, thus confirming their pain‑relieving effects. In addition, a significant increase in the mRNA and protein expression levels of P2X3 and P2X7 was detected in the DRG of rats in the CCI group compared with in the control groups; however, following treatment with a combination of ozone and Gardenoside, the mRNA and protein expression levels of P2X3 and P2X7 receptors were significantly reduced compared with in the CCI group.
CONCLUSIONS:
These results indicated that the mechanism underlying the pain‑relieving effects of ozone and Gardenoside may be mediated by inhibition of P2X3 and P2X7 purine receptors in the DRG. This finding suggested that ozone and Gardenoside may be considered potential drug candidates that target P2X3 and P2X7 purine receptors.

Structure Identification:

J Tradit Chin Med. 2002 Mar;22(1):55-60.

Effects of different compounding of formulae on content of gardenoside in Yin Chen Hao decoction.[Pubmed: 11977525]

METHODS AND RESULTS:
In order to observe the effects of the ground and intact Zhi Zi (Fructus Gardeniae) and different combinations of the ingredients and refined single Chinese drug granules in Yin Chen Hao Decoction compound prescription on the contents of Gardenoside (an effective component of the prescription), the contents of Gardenoside were determined with reversed phase high performance liquid chromatography (HPLC), with acetonitrile-water (15:85) as mobile phase, at wave length 238 nm.
CONCLUSIONS:
The results indicated that the Gardenoside-decocted-out rates in the decoctions prepared by different combinations of the ingredients with the ground Zhi Zi (Fructus Gardeniae) all were higher significantly than those in the decoction with intact Zhi Zi (Fructus Gardeniae), and generally, different combinations of the ingredients in the decoction had only little effect on the Gardenoside-decocted-out rate.

CAS No.	24512-62-7	Price	$768 / 20mg
Catalog No.	CFN90237	Purity	>=98%
Molecular Weight	404.37	Type of Compound	Iridoids
Formula	C₁₇H₂₄O₁₁	Physical Description	Powder
Download	Manual COA MSDS	Similar structural	Comparison (Web)

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.473 mL	12.3649 mL	24.7298 mL	49.4597 mL	61.8246 mL
5 mM	0.4946 mL	2.473 mL	4.946 mL	9.8919 mL	12.3649 mL
10 mM	0.2473 mL	1.2365 mL	2.473 mL	4.946 mL	6.1825 mL
50 mM	0.0495 mL	0.2473 mL	0.4946 mL	0.9892 mL	1.2365 mL
100 mM	0.0247 mL	0.1236 mL	0.2473 mL	0.4946 mL	0.6182 mL

CFN96588	Hastatoside	50816-24-5	404.37	C₁₇H₂₄O₁₁
CFN97199	Griselinoside	71035-06-8	432.4	C₁₈H₂₄O₁₂
CFN99492	Garjasmin	144868-43-9	224.2	C₁₁H₁₂O₅
CFN99447	Gardenine	139682-36-3	223.2	C₁₁H₁₃NO₄
CFN90237	Gardenoside	24512-62-7	404.37	C₁₇H₂₄O₁₁
CFN96355	Splendoside	81969-41-7	406.4	C₁₇H₂₆O₁₁
CFN90753	Dipsanoside A	889678-62-0	1475.4	C₆₆H₉₀O₃₇
CFN90754	Dipsanoside B	889678-64-2	1475.4	C₆₆H₉₀O₃₇
CFN89296	7-Deoxy-10-hydroxyloganetin	76267-48-6	228.24	C₁₁H₁₆O₅
CFN99858	Loganin	18524-94-2	390.4	C₁₇H₂₆O₁₀