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    Glycinol
    Glycinol
    Information
    CAS No. 69393-95-9 Price $398 / 5mg
    Catalog No.CFN95122Purity>=98%
    Molecular Weight272.3Type of CompoundFlavonoids
    FormulaC15H12O5Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Our products had been exported to the following research institutions and universities, And still growing.
  • Leibniz-Institut für Pflanzenbi... (Germany)
  • Agricultural Research Organizati... (Israel)
  • University of Amsterdam (Netherlands)
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    Biological Activity
    Description: Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells, it could as a potential preventive or treatment for osteoporosis. Glycinol also has antidiuretic activity.
    In vitro:
    Regen Med. 2017 Jul;12(5):513-524.
    Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells.[Pubmed: 28718749 ]
    Phytoestrogens, such as Glycinol, have recently gained significant attention as an alternative therapy for osteoporosis due to their structural similarity to estradiol and their bone-generating potential.
    METHODS AND RESULTS:
    The osteogenic effects of Glycinol were investigated in human bone marrow mesenchymal stem cells (BMSCs) derived from older (>50 years old) and younger subjects (<25 years old). BMSCs isolated from older donors demonstrated reduced osteogenesis. 17β-estradiol and Glycinol exposure rescued the age-related reduction in osteogenic differentiation of BMSCs. These results correlated with the induction of osteogenic genes and estrogen receptor-α (ER-α) following Glycinol treatment. ER antagonist studies further support that Glycinol promotes osteogenesis through ER signaling.
    CONCLUSIONS:
    The results from these studies support investigating Glycinol as a potential preventive or treatment for osteoporosis.
    In vivo:
    Eksp Klin Farmakol. 2010 Oct;73(10):21-4.
    [Influence of new neurohypophyseal hormone analogs on sodium and water reabsorption in rat kidney].[Pubmed: 21254509]
    New analogs of some neurohypophyseal hormones (oxypressin, hydrin, glumitocin, vasotocin) have been synthesized.
    METHODS AND RESULTS:
    Experiments with injection of these peptides to rats showed that substitution of C-terminal glycinamide on beta-ethanolamine (Glycinol) or ethylamine in 1-deamino-arginine vasotocin resulted in loss of natriuretic but not antidiuretic activity.
    CONCLUSIONS:
    Analogs of oxypressin and hydrin exhibited neither natriuretic activity nor ability to affect water reabsorption. Glumitocin analog induced renal sodium ion excretion and did not influence potassium ion excretion.
    Glycinol Description
    Source: The herbs of Derris robusta
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.6724 mL 18.3621 mL 36.7242 mL 73.4484 mL 91.8105 mL
    5 mM 0.7345 mL 3.6724 mL 7.3448 mL 14.6897 mL 18.3621 mL
    10 mM 0.3672 mL 1.8362 mL 3.6724 mL 7.3448 mL 9.1811 mL
    50 mM 0.0734 mL 0.3672 mL 0.7345 mL 1.469 mL 1.8362 mL
    100 mM 0.0367 mL 0.1836 mL 0.3672 mL 0.7345 mL 0.9181 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.