ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
More articles cited ChemFaces products.
J Bone Miner Res. 2017 Jul 26.Industrial Crops and Products2017 Jan.Scientific Reports2015 August 26 Evid Based Complement Alternat Med. 2018;Molecules 2016, 21(6)2016 Jun 22;21(6).
J Chromatogr Sci.2015 Feb 5. pii: bmu231. Food Chem.2018 Jun 30;Molecules. 2017 Jun 2;Front Pharmacol. 2017 Apr 25;J Drug Target.2016 Feb 24:1-28.
Int. J. of Food Properties08 Feb 2017;J Pharm Biomed Anal. 2016 Jun 25;129:50-59. Fitoterapia. 2018 Jan;PLoS One. 2015 May 15.
Our products had been exported to the following research institutions and universities, And still growing.
Monash University (Australia)Sri Sai Aditya Institute of Phar... (India)University of Fribourg (Switzerland)Lodz University of Technology (Poland)
University of Leipzig (Germany)Amity University (India)Wroclaw Medical University (Poland)University Medical Center Mainz (Germany)
Universite Libre de Bruxelles (Belgium)Chang Gung University (Taiwan)Anna University (India)
||1. Isosaponarin increases collagen synthesis in human fibroblasts, causes by up-regulated TbetaR-II and P4H production.|
||The seeds of Vaccaria segetalis
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi: 10.1016/j.phymed.2017.12.030.PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Isosaponarin References Information
J Nat Med. 2010 Jul;64(3):305-12.
|The effect of isosaponarin isolated from wasabi leaf on collagen synthesis in human fibroblasts and its underlying mechanism.[Pubmed: 20349148 ]|
|Wasabi has been used as an important spice in Japanese foods. The wasabi leaves were used as a cosmetic material, but its biological activities have not yet been examined. We investigated the effect of Isosaponarin derived from wasabi leaf on collagen synthesis in human fibroblasts. The production of type I collagen in human fibroblasts was increased with treatment of wasabi leaf extract. Isosaponarin isolated from wasabi leaves belonged to the group of flavone glycoside, and was the key compound in collagen synthesis from the wasabi leaf ingredients. Isosaponarin increased the type I collagen production at the mRNA gene level. The treatment of Isosaponarin did not influence the production of transforming growth factor-beta (TGF-beta) protein, but increased the production of TGF-beta type II receptor (TbetaR-II) protein and TbetaR-II mRNA. Prolyl 4-hydroxylase (P4H) protein and P4H mRNA were increased by treatment with Isosaponarin. Heat shock protein 47 (HSP47) was not increased by treatment with Isosaponarin. These results suggested that Isosaponarin increased collagen synthesis in human fibroblasts, caused by up-regulated TbetaR-II and P4H production.