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    Glycyrrhizic acid ammonium salt
    Information
    CAS No. 53956-04-0 Price $40 / 20mg
    Catalog No.CFN99153Purity>=98%
    Molecular Weight839.96Type of CompoundTriterpenoids
    FormulaC42H65NO16Physical DescriptionWhite powder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Glycyrrhizic acid ammonium salt has wound healing activity.
    Targets: ROS
    In vivo:
    Eksp Klin Farmakol. 2014;77(9):38-42.
    Study of the influence of original multicomponent gels on the process of pathological scar formation using new methodological approach.[Pubmed: 25365869]
    A new method of the quantitative macroscopic assessment of the process of a complex infected wound healing has been created. It was verified by example of the influence of original multicomponent gels consisting of cycloferon, amino acid glycine, glycyram (Glycyrrhizic acid ammonium salt), and vegetable oils on the process of infected wound healing and pathological scar formation. Simultaneously, the wound healing was monitored by the conventional histomorphological method. The proposed gels more effectively prevent the formation of pathological scars in comparison to reference preparation Contractubex.
    Glycyrrhizic acid ammonium salt Description
    Source: The roots of Glycyrrhiza glabra L.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.1905 mL 5.9527 mL 11.9053 mL 23.8107 mL 29.7633 mL
    5 mM 0.2381 mL 1.1905 mL 2.3811 mL 4.7621 mL 5.9527 mL
    10 mM 0.1191 mL 0.5953 mL 1.1905 mL 2.3811 mL 2.9763 mL
    50 mM 0.0238 mL 0.1191 mL 0.2381 mL 0.4762 mL 0.5953 mL
    100 mM 0.0119 mL 0.0595 mL 0.1191 mL 0.2381 mL 0.2976 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Animal Research:
    Ijrpbsonline Com., 2011.
    Pharmacological Investigation on the Wound Healing Effects of Glycyrrhizic Acid Ammonium Salt in Rats.[Reference: WebLink]
    Wound healing process involves several steps, which involves coagulation, inflammation, formation of granulation tissue, matrix formation, remodeling of connective tissue, collagenisation and aquisation of wound strength.Wound healing activity of GA was Glycyrrhizic acid ammonium salt (GA) studied in terms of 1) % wound contraction, 2) epithelization, 3) wound breaking strength in incision and excision wound models. In the standard group the rats were treated with 0.0005% w/w fluticasone ointment for 10 days in incision model and for 16 days in excision model. In the test group, the rats were treated with 2% w/w GA ointment for 10 days in incision model and for 16 days in excision model.
    CONCLUSIONS:
    In this study we have demonstrated the effect of Glycyrrhizic acid ammonium salt on excision and incision wound healing models that GA show increase the % wound contraction, epithelization and wound breaking strength as compared to control group